Association of Nek2A with MCC:APC/C

Stable Identifier
R-HSA-179410
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Nek2A does not appear to be recruited to the APC/C by Cdc20 but rather binds directly to the APC/C in an interaction involving the NEK2A C-terminal methionine‚Äďarginine (MR) dipeptide tail (Hayes et al., 2006).

Literature References
PubMed ID Title Journal Year
16648845 Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Hayes, MJ, Kimata, Y, Wattam, SL, Lindon, C, Mao, G, Yamano, H, Fry, AM

Nat Cell Biol 2006
11742988 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

Hames, RS, Wattam, SL, Yamano, H, Bacchieri, R, Fry, AM

EMBO J 2001
Participants
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