Reactome | CTLA4 [plasma membrane]

CTLA4 [plasma membrane]

Stable Identifier

R-HSA-179764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CTLA-4

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Locations in the PathwayBrowser for interactor UniProt:Q08050 FOXM1

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External Reference Information

External Reference

UniProt:P16410 CTLA4

Gene Names

CTLA4, CD152

Chain

signal peptide:1-35, chain:36-223

Reference Genes

BioGPS Gene:1493 CTLA4

COSMIC (genes):CTLA4 CTLA4

CTD Gene:1493 CTLA4

dbSNP Gene:1493 CTLA4

ENSEMBL:ENSG00000163599 CTLA4

HGNC:2505 CTLA4

KEGG:hsa:1493 CTLA4

Monarch:1493 CTLA4

NCBI Gene:1493 CTLA4

OMIM:123890 CTLA4

UCSC:P16410 CTLA4

Reference Transcript

Other Identifiers

11730636_a_at

11730637_a_at

11753826_x_at

11753866_x_at

1493

16889819

221331_PM_x_at

221331_x_at

231794_PM_at

231794_at

234362_PM_s_at

234362_s_at

236341_PM_at

236341_at

2523856

2523857

2523858

2523859

2523860

2523861

2523862

8047692

81915_at

A_14_P101727

A_23_P102481

A_33_P3396139

A_33_P3401556

GE62661

GO:0002250

GO:0002376

GO:0005515

GO:0005794

GO:0005886

GO:0006955

GO:0006974

GO:0009897

GO:0016020

GO:0030889

GO:0031410

GO:0042129

GO:0042130

GO:0043065

GO:0045334

GO:0045590

GO:0048471

GO:0050852

GO:0050853

GO:0098636

HMNXSV003041410

Hs.247824.2.S1_3p_a_at

Hs.313929.0.A1_3p_at

ILMN_1763487

ILMN_2261627

ILMN_2348905

M37245_at

PH_hs_0013114

TC02001201.hg

TC02003774.hg

Participates

as an output of

CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)

as a component of

CTLA4 dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y201,Y218-CTLA4 [plasma membrane]

Inferred To

CTLA-4 [plasma membrane] (Bos taurus)

CTLA4 [plasma membrane] (Gallus gallus)

CTLA4 [plasma membrane] (Sus scrofa)

CD152 [plasma membrane] (Canis familiaris)

Ctla4 [plasma membrane] (Mus musculus)

Ctla4 [plasma membrane] (Rattus norvegicus)

ctla4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005205.2, NP_001032720.1

Guide to Pharmacology - Targets

2743

OpenTargets

ENSG00000163599

ENSEMBL

ENST00000295854, ENSG00000163599, ENSP00000497319, ENST00000648405, ENSP00000295854, ENSP00000497102, ENST00000487393

HPA

ENSG00000163599-CTLA4

GeneCards

CTLA4

PRO

P16410

Pharos - Targets

P16410

Orphanet

CTLA4

GlyGen

P16410

PDB

5TRU, 8GAB, 7CIO, 7DV4, 6RP8, 6RQM, 7ELX, 5XJ3, 9DQ3, 8HIT, 7SU1, 1AH1, 6XY2, 7SU0, 1I8L, 6RPJ, 3OSK, 3BX7, 2X44, 1I85, 5GGV, 1H6E

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.876	10
UniProt:P42081 CD86	1	CD86 [plasma membrane] (R-HSA-179784)	0.838	6
UniProt:P50851 LRBA			0.669	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.643	3
UniProt:A2RU14 TM218			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q13021 MALL			0.556	3
UniProt:O43286 B4GALT5	1	B4GALT5 [Golgi membrane] (R-HSA-1015832)	0.527	2
UniProt:Q9BXJ8 TACAN			0.527	2
UniProt:Q9Y2U8 LEMD3	4	LEMD3 [endosome membrane] (R-HSA-9715091) LEMD3 [endoplasmic reticulum membrane] (R-HSA-9714458) LEMD3 [plasma membrane] (R-HSA-9715186) LEMD3 [nuclear envelope] (R-HSA-2993886)	0.527	2
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.527	2
UniProt:Q13332 PTPRS	1	PTPRS [plasma membrane] (R-HSA-197680)	0.527	2
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.527	2

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