Reactome | ADAM17 [plasma membrane]

ADAM17 [plasma membrane]

Stable Identifier

R-HSA-179878

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ADAM 17 metalloprotease, ADAM 17 sheddase, TACE

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P78536 ADAM17

Gene Names

ADAM17, CSVP, TACE

Chain

signal peptide:1-17, propeptide:18-214, chain:215-824

Reference Genes

BioGPS Gene:6868 ADAM17

COSMIC (genes):ADAM17 ADAM17

CTD Gene:6868 ADAM17

dbSNP Gene:6868 ADAM17

ENSEMBL:ENSG00000151694 ADAM17

HGNC:195 ADAM17

KEGG:hsa:6868 ADAM17

Monarch:6868 ADAM17

NCBI Gene:6868 ADAM17

OMIM:603639 ADAM17

UCSC:P78536 ADAM17

Reference Transcript

RefSeq:NM_003183.5 ADAM17

Other Identifiers

11731109_a_at

11731110_at

11747645_a_at

11762039_at

1226_at

1227_g_at

16894335

205745_PM_x_at

205745_x_at

205746_PM_s_at

205746_s_at

213532_PM_at

213532_at

2539820

2539822

2539823

2539824

2539825

2539826

2539827

2539828

2539829

2539830

2539831

2539832

2539833

2539834

2539835

2539836

2539838

2539839

2539840

2539841

2539842

2539843

2539844

2539845

2539846

2539847

2539849

2539850

2539852

2539855

2539856

2539857

2539862

3925973

3959680

41601_at

6868

7895004

8050190

A_23_P143120

A_24_P157053

A_32_P129621

GE59572

GO:0000139

GO:0001666

GO:0002376

GO:0002446

GO:0002467

GO:0002690

GO:0003824

GO:0004175

GO:0004222

GO:0005112

GO:0005138

GO:0005178

GO:0005515

GO:0005737

GO:0005788

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0006508

GO:0006509

GO:0007155

GO:0007173

GO:0007219

GO:0007220

GO:0008233

GO:0008237

GO:0008284

GO:0009410

GO:0009986

GO:0010820

GO:0015629

GO:0016020

GO:0016324

GO:0016485

GO:0016787

GO:0017124

GO:0019955

GO:0023061

GO:0030154

GO:0030165

GO:0030183

GO:0030307

GO:0030335

GO:0030512

GO:0032496

GO:0032587

GO:0032722

GO:0032760

GO:0033025

GO:0033077

GO:0033627

GO:0035313

GO:0042987

GO:0043120

GO:0043226

GO:0043491

GO:0043536

GO:0045121

GO:0045741

GO:0045742

GO:0046872

GO:0048536

GO:0048856

GO:0048870

GO:0050830

GO:0051128

GO:0051604

GO:0071403

GO:0071679

GO:0098542

GO:0120163

GO:0140096

GO:1900087

GO:1902945

GO:1903265

GO:1905564

HMNXSV003048247

Hs.52438.1.A1_3p_at

ILMN_1765779

ILMN_2121068

PH_hs_0024641

TC02001558.hg

U69611_at

U86755_s_at

g11497003_3p_a_at

g1857672_3p_a_at

Participates

as a member of

as a component of

ADAM17 [plasma membrane] (Homo sapiens)

as a candidate of

ADAM10/17 [plasma membrane] (Homo sapiens)

Other forms of this molecule

ADAM17(215-827) [plasma membrane]

ADAM17 [Golgi membrane]

ADAM17(1-214) [Golgi membrane]

ADAM17(215-827) [Golgi membrane]

ADAM17 [endoplasmic reticulum lumen]

Inferred To

ADAM17 [plasma membrane] (Bos taurus)

ADAM17 [plasma membrane] (Canis familiaris)

ADAM17 [plasma membrane] (Sus scrofa)

Adam17 [plasma membrane] (Mus musculus)

Adam17 [plasma membrane] (Rattus norvegicus)

adam17 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003174.3

ZINC - World Drugs

ADA17_HUMAN

Guide to Pharmacology - Targets

1662

OpenTargets

ENSG00000151694

ENSEMBL

ENSG00000151694, ENSP00000309968, ENST00000310823

ZINC - Substances

ADA17_HUMAN

ZINC target

P78536

PRO

P78536

GlyGen

P78536

PDB

2OI0, 3LGP, 2M2F, 1BKC, 3G42, 1ZXC, 2FV5, 2FV9, 8CQY, 9E6K, 3O64, 3B92, 3EDZ, 2DDF, 3EWJ, 3KME, 3E8R, 3LE9, 8SNL, 3CKI, 8SNN, 3KMC, 3LEA, 8SNO, 3L0T, 2I47, 3L0V, 2A8H

ZINC - Investigational

ADA17_HUMAN

IntEnz

3.4.24.86

HPA

ENSG00000151694-ADAM17

GeneCards

ADAM17

Pharos - Targets

P78536

Orphanet

ADAM17

ZINC - Predictions - Purchasable

ADA17_HUMAN

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [cytosol] (R-HSA-416332) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593)	0.65	7
UniProt:P05556 ITGB1	2	ITGB1 [plasma membrane] (R-HSA-57596) ITGB1 [endosome membrane] (R-HSA-9611157)	0.609	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.597	3
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.581	3
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	3
UniProt:P35625 TIMP3	2	TIMP3 [extracellular region] (R-HSA-1430774) TIMP3 [platelet dense granule lumen] (R-HSA-8848904)	0.527	2
UniProt:Q9H0V9 LMAN2L	3	LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689834) LMAN2L [ER to Golgi transport vesicle membrane] (R-HSA-5689832) LMAN2L [endoplasmic reticulum membrane] (R-HSA-5689469)	0.527	2
UniProt:Q80WQ6 RHDF2			0.524	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5