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ADAM17 [plasma membrane]
Stable Identifier
R-HSA-179878
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ADAM 17 metalloprotease, ADAM 17 sheddase, TACE
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type XVII ectodomain shedding (Homo sapiens)
Collagen type XVII sheddases [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
Metalloprotease cleavage of GHR (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
TNF-alpha is cleaved by ADAM17 (TACE) (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
Release of Hh-Np from the secreting cell (Homo sapiens)
Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
Pro-EGF is cleaved to form mature EGF (Homo sapiens)
ADAM:Zn2+ [plasma membrane] (Homo sapiens)
ADAM metalloprotease [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
ADAM17 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78536 ADAM17
Gene Names
ADAM17, CSVP, TACE
Chain
signal peptide:1-17, propeptide:18-214, chain:215-824
Reference Genes
BioGPS Gene:6868 ADAM17
COSMIC (genes):ADAM17 ADAM17
CTD Gene:6868 ADAM17
dbSNP Gene:6868 ADAM17
ENSEMBL:ENSG00000151694 ADAM17
HGNC:195 ADAM17
KEGG Gene (Homo sapiens):6868 ADAM17
Monarch:6868 ADAM17
NCBI Gene:6868 ADAM17
OMIM:603639 ADAM17
UCSC:P78536 ADAM17
Reference Transcript
RefSeq:NM_003183.5 ADAM17
Other Identifiers
0003850411
11731109_a_at
11731110_at
11747645_a_at
1226_at
1227_g_at
16894335
205745_x_at
205746_s_at
213532_at
2539822
2539823
2539824
2539825
2539826
2539828
2539829
2539833
2539834
2539835
2539836
2539838
2539839
2539840
2539841
2539844
2539846
2539849
2539850
2539852
2539855
2539856
2539857
41601_at
6868
8050190
A_23_P143120
A_24_P157053
A_32_P129621
GE59572
GO:0000278
GO:0001666
GO:0001934
GO:0002376
GO:0002446
GO:0002467
GO:0002690
GO:0003674
GO:0004175
GO:0004222
GO:0005112
GO:0005138
GO:0005178
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005887
GO:0005911
GO:0005925
GO:0006464
GO:0006508
GO:0006509
GO:0006950
GO:0007049
GO:0007155
GO:0007165
GO:0007173
GO:0007219
GO:0007220
GO:0008150
GO:0008219
GO:0008233
GO:0008237
GO:0008283
GO:0008284
GO:0009986
GO:0010820
GO:0015629
GO:0016020
GO:0016021
GO:0016324
GO:0016787
GO:0017124
GO:0030154
GO:0030165
GO:0030183
GO:0030307
GO:0030335
GO:0030511
GO:0030512
GO:0031293
GO:0032496
GO:0032587
GO:0032722
GO:0033025
GO:0033077
GO:0033209
GO:0033627
GO:0035313
GO:0035624
GO:0040007
GO:0040011
GO:0042493
GO:0042592
GO:0043167
GO:0043226
GO:0043536
GO:0045121
GO:0045737
GO:0045741
GO:0046872
GO:0048536
GO:0048646
GO:0048856
GO:0048870
GO:0050830
GO:0051088
GO:0051272
GO:0071403
GO:0120163
GO:1900087
GO:1903265
GO:1905564
Hs.52438.1.A1_3p_at
ILMN_1765779
ILMN_2121068
PH_hs_0024641
TC02001558.hg
U69611_at
U86755_s_at
g11497003_3p_a_at
g1857672_3p_a_at
Participant Of
hasMember
ADAM metalloprotease [plasma membrane]
Collagen type XVII sheddases [plasma membrane]
hasComponent
ADAM17 [plasma membrane]
hasCandidate
ADAM10/17 [plasma membrane]
Other forms of this molecule
ADAM17 [endoplasmic reticulum lumen]
ADAM17(215-827) [Golgi membrane]
ADAM17(1-214) [Golgi membrane]
ADAM17 [Golgi membrane]
ADAM17(215-827) [plasma membrane]
Inferred To
ADAM17 [plasma membrane] (Bos taurus)
ADAM17 [plasma membrane] (Canis familiaris)
Adam17 [plasma membrane] (Mus musculus)
Adam17 [plasma membrane] (Rattus norvegicus)
adam17 [plasma membrane] (Xenopus tropicalis)
adam17a [plasma membrane] (Danio rerio)
Cross References
RefSeq
NP_003174.3
ZINC - World Drugs
ADA17_HUMAN
OpenTargets
ENSG00000151694
ZINC - Substances
ADA17_HUMAN
ZINC target
P78536
PRO
P78536
PDB
2I47
,
2DDF
,
1BKC
,
2A8H
,
3L0T
,
3LGP
,
3LE9
,
2FV5
,
1ZXC
,
2FV9
,
3KMC
,
3E8R
,
3CKI
,
3G42
,
3O64
,
2OI0
,
3KME
,
3LEA
,
2M2F
,
3B92
,
3EWJ
,
3L0V
,
3EDZ
ZINC - Investigational
ADA17_HUMAN
IntEnz
3.4.24.86
HPA
ENSG00000151694-ADAM17
GeneCards
P78536
Ensembl
ENST00000310823
,
ENSG00000151694
,
ENSP00000309968
ZINC - Predictions - Purchasable
ADA17_HUMAN
Orphanet
21088
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12959 DLG1
4
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [plasma membrane]
(R-HSA-375977)
0.65
7
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.609
2
UniProt:P21926 CD9
4
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.597
3
UniProt:Q13257 MAD2L1
2
Activated MAD2L1 [cytosol]
(R-HSA-141447)
MAD2L1 [cytosol]
(R-HSA-141400)
0.581
3
UniProt:Q80WQ6 RHDF2
0.524
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.463
2
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