The SRP receptor binds the SRP:nascent peptide:ribosome complex

Stable Identifier
R-HSA-1799330
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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The SRP receptor binds the SRP:nascent peptide:ribosome complex
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The SRP receptor in the the endoplasmic reticulum (ER) membrane binds via its alpha subunit to the the SRP54 subunit of the Signal Recognition Particle (SRP), which itself is bound to a ribosome:mRNA:polypeptide complex. This interaction tethers the ribosome to the ER membrane, oriented so that the nacent polypeptide will traverse the ER membrane and enter the ER lumen. This process has been characterized in detail in cultured canine cells; this human event is inferred by homology from its canine counterpart.
Literature References
PubMed ID Title Journal Year
9631292 The role of assembly in insulin's biosynthesis

Steiner, D, Dodson, G

Curr Opin Struct Biol 1998
12853463 Structure, function and evolution of the signal recognition particle

Nagai, K, Jovine, L, Isel, C, Oubridge, C, Menichelli, E, Kuglstatter, A

EMBO J 2003
Participants
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as an event of
Inferred From
SRP binds SRP Receptor (Canis familiaris) (Canis familiaris)
Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
D'Eustachio, P  (2011-10-23)
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