Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)

Stable Identifier
R-HSA-1799332
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The Ribosome Nascent Complex containing the ribosome and protruding signal peptide of preprolactin is bound by the Signal Recognition Particle Complex. Translation is paused during this step.

Literature References
PubMed ID Title Journal Year
12853463 Structure, function and evolution of the signal recognition particle

Nagai, K, Oubridge, C, Kuglstatter, A, Menichelli, E, Isel, C, Jovine, L

EMBO J 2003
16469117 Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages

Römisch, K, Miller, FW, Dobberstein, B, High, S

Arthritis Res Ther 2006
18455985 SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites

Lakkaraju, AK, Mary, C, Scherrer, A, Johnson, AE, Strub, K

Cell 2008
Participants
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Orthologous Events
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