Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)

Stable Identifier
R-HSA-1799332
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
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The Ribosome Nascent Complex containing the ribosome and protruding signal peptide of preprolactin is bound by the Signal Recognition Particle Complex. Translation is paused during this step.
Literature References
PubMed ID Title Journal Year
16469117 Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages

High, S, Dobberstein, B, Miller, FW, Römisch, K

Arthritis Res Ther 2006
12853463 Structure, function and evolution of the signal recognition particle

Nagai, K, Jovine, L, Isel, C, Oubridge, C, Menichelli, E, Kuglstatter, A

EMBO J 2003
18455985 SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites

Strub, K, Scherrer, A, Lakkaraju, AK, Johnson, AE, Mary, C

Cell 2008
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Orthologous Events
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Bos taurus)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Danio rerio)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Drosophila melanogaster)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Plasmodium falciparum)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)
Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
D'Eustachio, P  (2011-10-23)
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