DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function

Stable Identifier
R-HSA-180038
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DARPP-32 is phosphorylated by cAMP-dependent protein kinase (PKA) on a single threonine residue, Thr34, resulting in its conversion into a potent inhibitor of protein phosphatase-1.

Literature References
PubMed ID Title Journal Year
6087160 DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

Hemmings HC, Jr, Greengard, P, Tung, HY, Cohen, P

Nature 1984
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein phosphatase regulator activity of Phosphorylated (T34) DARPP-32:PP1A [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created