CDK5 phosphorylates DARPP-32 on Thr75

Stable Identifier
R-HSA-180047
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The amino-acid sequence of DARPP-32 contains consensus phosphorylation sites for proline-directed kinases, including Cdk5, a cyclin-dependent kinase family member which is present in post-mitotic neurons expressing high levels of DARPP-32.

Literature References
PubMed ID Title Journal Year
10604473 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

Bibb, JA, Snyder, GL, Nishi, A, Yan, Z, Meijer, L, Fienberg, AA, Tsai, LH, Kwon, YT, Girault, JA, Czernik, AJ, Huganir, RL, Hemmings HC, Jr, Nairn, AC, Greengard, P

Nature 1999
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CDK5 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created