SHC1 events in EGFR signaling

Stable Identifier
R-HSA-180336
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

GRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.

Literature References
PubMed ID Title Journal Year
11498013 Internalization of the epidermal growth factor receptor: role in signalling

Sorkin, A

Biochem Soc Trans 2001
8755247 Not all Shc's roads lead to Ras

Bonfini, L, Migliaccio, E, Pelicci, G, Lanfrancone, L, Pelicci, PG

Trends Biochem Sci 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed