Reactome | PXN [plasma membrane]

PXN [plasma membrane]

Stable Identifier

R-HSA-180493

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Paxillin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49023 PXN

Gene Names

PXN

Chain

initiator methionine:, chain:1-591

Reference Genes

BioGPS Gene:5829 PXN

COSMIC (genes):PXN PXN

CTD Gene:5829 PXN

dbSNP Gene:5829 PXN

ENSEMBL:ENSG00000089159 PXN

ENSEMBL:ENSG00000089159.17 PXN

HGNC:9718 PXN

KEGG Gene (Homo sapiens):5829 PXN

Monarch:5829 PXN

NCBI Gene:5829 PXN

OMIM:602505 PXN

UCSC:P49023 PXN

Reference Transcript

Other Identifiers

11717617_a_at

11717618_s_at

11736017_s_at

11736018_x_at

11748796_a_at

11749054_x_at

11752827_a_at

11752828_x_at

16771242

201087_PM_at

201087_at

211823_PM_s_at

211823_s_at

3474373

3474374

3474375

3474376

3474377

3474378

3474379

3474380

3474384

3474385

3474386

3474387

3474388

3474390

3474402

3474403

3474404

3474405

3474406

3474407

3474416

3474417

38644_at

5829

7967002

A_24_P184555

A_33_P3380098

GE58953

GO:0001725

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005875

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0007010

GO:0007155

GO:0007165

GO:0007172

GO:0007179

GO:0008013

GO:0008092

GO:0016477

GO:0017166

GO:0019903

GO:0023052

GO:0030027

GO:0030154

GO:0034446

GO:0034614

GO:0038191

GO:0043226

GO:0043542

GO:0046872

GO:0048856

GO:0048870

GO:0051496

GO:0060396

GO:0065003

GO:0070161

HMNXSV003050935

TC12002037.hg

U14588_at

g1912054_3p_a_at

g4506344_3p_at

Participates

as a component of

as an input of

PARVA associates with Paxillin (Homo sapiens)

Other forms of this molecule

p-Y-PXN [plasma membrane]

PXN [cytosol]

p-Y31,Y118-PXN [cytosol]

Inferred To

pxn [plasma membrane] (Xenopus tropicalis)

limB [plasma membrane] (Dictyostelium discoideum)

Pxn [plasma membrane] (Mus musculus)

Pxn [plasma membrane] (Rattus norvegicus)

Pax [plasma membrane] (Drosophila melanogaster)

pxl-1 [plasma membrane] (Caenorhabditis elegans)

limA [plasma membrane] (Dictyostelium discoideum)

PXN [plasma membrane] (Bos taurus)

PXN [plasma membrane] (Canis familiaris)

PXN [plasma membrane] (Danio rerio)

PXN [plasma membrane] (Gallus gallus)

PXN [plasma membrane] (Sus scrofa)

Homologues of PXN [plasma membrane] (Dictyostelium discoideum)

paxB [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

XP_016875232.1, NP_002850.2, NP_001230685.1, NP_001074324.1, NP_079433.3

OpenTargets

ENSG00000089159

HPA

ENSG00000089159-PXN

GeneCards

P49023

Ensembl

ENSG00000089159, ENST00000267257, ENST00000458477, ENSP00000228307, ENSP00000391283, ENSP00000267257, ENSP00000395536, ENST00000424649, ENST00000228307

PRO

P49023

Pharos - Targets

P49023

PDB

2VZI, 6U4N, 1OW8, 3GM1, 1OW7, 3U3F, 2O9V, 3PY7, 2VZG, 2K2R, 4XH2, 4EDN, 3RQE, 5UWH, 2VZD, 7QB0, 3RQG, 4R32, 3RQF, 1OW6, 6U4M, 6PW8, 4XGZ, 6IUI

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.937	18
UniProt:P06931 VE6			0.744	4
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.688	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.688	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.669	4
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.623	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:Q62417-2 SORBS1			0.61	8
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.604	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.602	4
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.591	6
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.571	2
UniProt:Q9Y2X7 GIT1	2	p-Y383-GIT1 [cytosol] (R-HSA-3928463) GIT1 [cytosol] (R-HSA-430326)	0.564	3
UniProt:Q14289 PTK2B	3	p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721)	0.527	2
UniProt:Q09463	2	rnf-5 [endoplasmic reticulum membrane] (R-CEL-8861819) rnf-5 [endoplasmic reticulum membrane] (R-CEL-975990)	0.524	2
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.499	2
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.491	2
UniProt:O13016 PTN1			0.489	2
UniProt:P34152 Ptk2	2	p-Y428-FAK1 [cytosol] (R-MMU-3928397) Fak1 [cytosol] (R-MMU-3928448)	0.463	2
UniProt:P16671 CD36	5	CD36 [platelet alpha granule membrane] (R-HSA-114687) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.462	2

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