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PXN [plasma membrane]
Stable Identifier
R-HSA-180493
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Paxillin
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
PARVA associates with Paxillin (Homo sapiens)
PARVA:Paxillin [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
PARVA associates with Paxillin (Homo sapiens)
PARVA:Paxillin [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal ahesion complex [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
PXN:MyrG-SRC [plasma membrane] (Homo sapiens)
PXN [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49023 PXN
Gene Names
PXN
Chain
initiator methionine:, chain:1-591
Reference Genes
BioGPS Gene:5829 PXN
COSMIC (genes):PXN PXN
CTD Gene:5829 PXN
dbSNP Gene:5829 PXN
ENSEMBL:ENSG00000089159 PXN
HGNC:9718 PXN
KEGG Gene (Homo sapiens):5829 PXN
Monarch:5829 PXN
NCBI Gene:5829 PXN
OMIM:602505 PXN
UCSC:P49023 PXN
Reference Transcript
RefSeq:NM_001243756.1 PXN
RefSeq:XM_017019743.1 PXN
RefSeq:NM_002859.3 PXN
RefSeq:NM_025157.4 PXN
RefSeq:NM_001080855.2 PXN
Other Identifiers
11717617_a_at
11717618_s_at
11736017_s_at
11736018_x_at
11748796_a_at
11749054_x_at
11752827_a_at
11752828_x_at
16771242
201087_at
211823_s_at
3474373
3474374
3474375
3474376
3474377
3474378
3474379
3474380
3474384
3474385
3474386
3474387
3474388
3474390
3474402
3474403
3474404
3474405
3474406
3474407
3474416
3474417
38644_at
5829
7967002
A_24_P184555
A_33_P3380098
GE58953
GO:0000902
GO:0001725
GO:0003674
GO:0003712
GO:0005178
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005875
GO:0005886
GO:0005911
GO:0005925
GO:0005938
GO:0006936
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007172
GO:0007179
GO:0008013
GO:0008092
GO:0008150
GO:0009058
GO:0017166
GO:0019899
GO:0019901
GO:0019903
GO:0022607
GO:0030027
GO:0030054
GO:0030154
GO:0031625
GO:0032991
GO:0034446
GO:0034614
GO:0034641
GO:0038191
GO:0040011
GO:0043167
GO:0043226
GO:0043542
GO:0044877
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0051496
GO:0060396
GO:0065003
GO:1901652
GO:1903506
TC12002037.hg
U14588_at
g1912054_3p_a_at
g4506344_3p_at
Participant Of
hasComponent
integrin:cytoskeletal ahesion complex [plasma membrane]
PARVA:Paxillin [plasma membrane]
PXN:MyrG-SRC [plasma membrane]
input
PARVA associates with Paxillin
Other forms of this molecule
p-Y-PXN [plasma membrane]
PXN [cytosol]
p-Y31,Y118-PXN [cytosol]
Inferred To
pxn [plasma membrane] (Xenopus tropicalis)
PXL1 [plasma membrane] (Saccharomyces cerevisiae)
limB [plasma membrane] (Dictyostelium discoideum)
Pxn [plasma membrane] (Mus musculus)
Pxn [plasma membrane] (Rattus norvegicus)
Pax [plasma membrane] (Drosophila melanogaster)
pxl-1 [plasma membrane] (Caenorhabditis elegans)
PXN [plasma membrane] (Bos taurus)
PXN [plasma membrane] (Canis familiaris)
PXN [plasma membrane] (Schizosaccharomyces pombe)
PXN [plasma membrane] (Sus scrofa)
pxna [plasma membrane] (Danio rerio)
Cross References
RefSeq
XP_016875232.1
,
NP_001074324.1
,
NP_002850.2
,
NP_001230685.1
,
NP_079433.3
OpenTargets
ENSG00000089159
GeneCards
P49023
HPA
ENSG00000089159-PXN
Ensembl
ENST00000458477
,
ENSP00000228307
,
ENSP00000267257
,
ENSP00000391283
,
ENST00000267257
,
ENSG00000089159
,
ENSP00000395536
,
ENST00000228307
,
ENST00000424649
PRO
P49023
PDB
1OW8
,
3GM1
,
2K2R
,
5UWH
,
2VZD
,
3U3F
,
1OW7
,
3RQG
,
6IUI
,
4R32
,
4XGZ
,
4XH2
,
3RQF
,
1OW6
,
2VZI
,
6U4N
,
6U4M
,
1KL0
,
3RQE
,
2O9V
,
4EDN
,
2VZG
,
1KKY
,
3PY7
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05397 PTK2
11
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.91
17
UniProt:P06931 VE6
0.744
4
UniProt:Q14161 GIT2
0.688
4
UniProt:P13612 ITGA4
1
ITGA4 [plasma membrane]
(R-HSA-198007)
0.688
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.669
4
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.641
3
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.623
4
UniProt:Q62417-2 SORBS1
0.61
8
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.602
4
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.591
6
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.589
2
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.564
3
UniProt:P05556-1 ITGB1
0.524
2
UniProt:Q09463
2
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-975990)
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-8861819)
0.524
2
UniProt:Q13480 GAB1
4
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
GAB1 [cytosol]
(R-HSA-179795)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.499
2
UniProt:P02751 FN1
8
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.491
2
UniProt:O13016 PTN1
0.489
2
UniProt:P34152 Ptk2
13
phospho-Ptk2 [cytosol]
(R-MMU-8874613)
phospho-Ptk2 [cytosol]
(R-MMU-9632393)
phospho-Ptk2 [cytosol]
(R-MMU-354128)
phospho-Ptk2 [cytosol]
(R-MMU-354068)
Ptk2 [cytosol]
(R-MMU-201621)
phospho-Ptk2 [cytosol]
(R-MMU-5218694)
phospho-Ptk2 [cytosol]
(R-MMU-5229006)
phospho-Ptk2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
Ptk2 [cytosol]
(R-MMU-202827)
Ptk2 [cytosol]
(R-MMU-202829)
phospho-Ptk2 [cytosol]
(R-MMU-8874600)
0.463
2
UniProt:P16671 CD36
5
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
0.462
2
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