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p-Y627,Y659-GAB1 [cytosol]
Stable Identifier
R-HSA-180496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-GAB1(-Y447, Y472, Y589), Phosphorylated GRB2-associated binding protein 1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)
GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13480 GAB1
Gene Names
GAB1
Chain
initiator methionine:, chain:2-694
Reference Genes
BioGPS Gene:2549 GAB1
COSMIC (genes):GAB1 GAB1
CTD Gene:2549 GAB1
dbSNP Gene:2549 GAB1
ENSEMBL:ENSG00000109458 GAB1
HGNC:4066 GAB1
KEGG:hsa:2549 GAB1
Monarch:2549 GAB1
NCBI Gene:2549 GAB1
OMIM:604439 GAB1
UCSC:Q13480 GAB1
Reference Transcript
RefSeq:NM_207123.3 GAB1
RefSeq:NM_002039.3 GAB1
Participates
as a component of
GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
Other forms of this molecule
GAB1 [cytosol]
p-5Y-GAB1 [cytosol]
p-Y-GAB1 [cytosol]
Inferred To
phospho-gab1 [cytosol]
(Xenopus tropicalis)
phospho-GAB1 [cytosol]
(Bos taurus)
phospho-GAB1 [cytosol]
(Canis familiaris)
phospho-GAB1 [cytosol]
(Sus scrofa)
phospho-Gab1 [cytosol]
(Mus musculus)
phospho-Gab1 [cytosol]
(Rattus norvegicus)
phospho-dos [cytosol]
(Drosophila melanogaster)
phospho-p-Y627,Y659-GAB1 [cytosol]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 627
Coordinate
627
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 659
Coordinate
659
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_997006.1
,
NP_002030.2
OpenTargets
ENSG00000109458
ENSEMBL
ENST00000262995
,
ENST00000262994
,
ENSP00000262994
,
ENSP00000262995
,
ENSG00000109458
HPA
ENSG00000109458-GAB1
GeneCards
GAB1
PRO
Q13480
Pharos - Targets
Q13480
GlyGen
Q13480
PDB
4QSY
HMDB Protein
HMDBP13426
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.957
42
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.933
14
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.796
33
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.753
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.735
5
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.702
4
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.609
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.59
37
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.59
25
UniProt:Q9UNN4 TF2AY
0.556
3
UniProt:Q06124-2 PTPN11
0.544
2
UniProt:P49023 PXN
4
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
PXN [cytosol]
(R-HSA-210014)
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
0.499
2
UniProt:P50904
1
Rasa1 [cytosol]
(R-RNO-186833)
0.499
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
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