Reactome | p-Y627,Y659-GAB1 [cytosol]

p-Y627,Y659-GAB1 [cytosol]

Stable Identifier

R-HSA-180496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-GAB1(-Y447, Y472, Y589), Phosphorylated GRB2-associated binding protein 1

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - GAB1 signalosome (Homo sapiens)
      - Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Homo sapiens)
        
        GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
        
        p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)
        
        GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Homo sapiens)
        
        GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
        
        p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13480 GAB1

Gene Names

GAB1

Chain

initiator methionine:, chain:2-694

Reference Genes

BioGPS Gene:2549 GAB1

COSMIC (genes):GAB1 GAB1

CTD Gene:2549 GAB1

dbSNP Gene:2549 GAB1

ENSEMBL:ENSG00000109458 GAB1

HGNC:4066 GAB1

KEGG:hsa:2549 GAB1

Monarch:2549 GAB1

NCBI Gene:2549 GAB1

OMIM:604439 GAB1

UCSC:Q13480 GAB1

Reference Transcript

Participates

as a component of

GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)

Other forms of this molecule

GAB1 [cytosol]

p-5Y-GAB1 [cytosol]

p-Y-GAB1 [cytosol]

Inferred To

phospho-gab1 [cytosol] (Xenopus tropicalis)

phospho-GAB1 [cytosol] (Bos taurus)

phospho-GAB1 [cytosol] (Canis familiaris)

phospho-GAB1 [cytosol] (Sus scrofa)

phospho-Gab1 [cytosol] (Mus musculus)

phospho-Gab1 [cytosol] (Rattus norvegicus)

phospho-dos [cytosol] (Drosophila melanogaster)

phospho-p-Y627,Y659-GAB1 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 627

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 659

Coordinate

659

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_997006.1, NP_002030.2

OpenTargets

ENSG00000109458

ENSEMBL

ENST00000262995, ENST00000262994, ENSP00000262994, ENSP00000262995, ENSG00000109458

HPA

ENSG00000109458-GAB1

GeneCards

GAB1

PRO

Q13480

Pharos - Targets

Q13480

GlyGen

Q13480

PDB

4QSY

HMDB Protein

HMDBP13426

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.957	42
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.933	14
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.796	33
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.753	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.735	5
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.702	4
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.609	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.59	37
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.59	25
UniProt:Q9UNN4 TF2AY			0.556	3
UniProt:Q06124-2 PTPN11			0.544	2
UniProt:P49023 PXN	4	p-Y31,Y118-PXN [cytosol] (R-HSA-5218693) PXN [cytosol] (R-HSA-210014) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493)	0.499	2
UniProt:P50904	1	Rasa1 [cytosol] (R-RNO-186833)	0.499	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.483	2

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