Reactome | p-Y627,Y659-GAB1 [cytosol]

p-Y627,Y659-GAB1 [cytosol]

Stable Identifier

R-HSA-180496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-GAB1(-Y447, Y472, Y589), Phosphorylated GRB2-associated binding protein 1

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - GAB1 signalosome (Homo sapiens)
      - Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
        
        GRB2:p-Y627,Y659-GAB1,GRB2:p-Y627,Y659-GAB1:PIP3 [plasma membrane] (Homo sapiens)
        
        GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
        
        p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)
        
        GRB2:p-GAB1(partially dephosphorylated):PIP3 [plasma membrane] (Homo sapiens)
        
        GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol] (Homo sapiens)
        
        p-Y627,Y659-GAB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13480 GAB1

Gene Names

GAB1

Chain

initiator methionine:1, chain:2-694

Reference Genes

BioGPS Gene:2549 GAB1

COSMIC (genes):GAB1 GAB1

CTD Gene:2549 GAB1

dbSNP Gene:2549 GAB1

ENSEMBL:ENSG00000109458 GAB1

HGNC:4066 GAB1

KEGG Gene (Homo sapiens):2549 GAB1

Monarch:2549 GAB1

NCBI Gene:2549 GAB1

OMIM:604439 GAB1

UCSC:Q13480 GAB1

Reference Transcript

Other Identifiers

0000460341

11731635_a_at

11731636_a_at

11731637_s_at

11731638_a_at

11731639_a_at

11741339_a_at

11741340_a_at

11747982_a_at

1249_at

16971019

207112_s_at

214987_at

225998_at

226002_at

229114_at

2549

2745549

2745550

2745551

2745552

2745553

2745554

2745588

2745606

2745607

2745610

2745612

2745613

2745620

2745621

2745622

2745625

2745626

2745627

2745628

2745629

2745630

2745647

2745648

32979_at

33997_at

34333

49599

4QSY

56088_at

56736_r_at

60488_at

8097586

A_14_P125611

A_23_P18505

A_23_P335239

A_24_P936319

AAC50380

AAH64848

AAY26398

AAY40964

AC097658

AC104685

AK289767

B7Z3B9

BAF82456

BC064848

CAB034333

CCDS3759

CCDS3760

CH471056

D6RF42

D6RIF8

D6RIS0

DQ021880

EAX05072

ENSG00000109458

ENSP00000262994

ENSP00000262995

ENST00000262994

ENST00000262994.8

ENST00000262995

ENST00000262995.8

EntrezGene:2549

EntrezGene:GAB1

g4503850_3p_a_at

GAB1

GAB1-201

GAB1-202

GE56182

GE79393

GO:0000902

GO:0001525

GO:0003674

GO:0005070

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0007010

GO:0007165

GO:0007173

GO:0007411

GO:0008150

GO:0008286

GO:0014068

GO:0030154

GO:0030674

GO:0031532

GO:0035728

GO:0038084

GO:0038089

GO:0038128

GO:0040011

GO:0045766

GO:0048646

GO:0048856

GO:0048870

GO:0051897

GO:0090668

HGNC:4066

HPA049599

Hs.239706.1.S1_3p_at

Hs.239706.1.S2_3p_at

Hs.27519.0.A1_3p_at

Hs.80720.0.S1_3p_at

ILMN_1666910

ILMN_1781672

ILMN_2405534

IPR001849

IPR011993

MIM:604439

MIM:605428

NM_002039

NM_207123

NP_002030

NP_997006

PF00169

PH_hs_0022194

SM00233

TC04000699.hg

U43885

U43885_at

UPI000013D37B

UPI0000232A33

XM_017007966

XM_017007967

XM_017007968

XP_016863455

XP_016863456

XP_016863457

Participant Of

hasComponent

GRB2:Phospho-GAB1(partially dephosphorylated) [cytosol]

Other forms of this molecule

p-Y-GAB1 [cytosol]

p-5Y-GAB1 [cytosol]

GAB1 [cytosol]

Inferred To

phospho-p-Y627,Y659-GAB1 [cytosol] (Bos taurus)

phospho-p-Y627,Y659-GAB1 [cytosol] (Caenorhabditis elegans)

phospho-p-Y627,Y659-GAB1 [cytosol] (Canis familiaris)

phospho-p-Y627,Y659-GAB1 [cytosol] (Danio rerio)

phospho-p-Y627,Y659-GAB1 [cytosol] (Drosophila melanogaster)

phospho-p-Y627,Y659-GAB1 [cytosol] (Gallus gallus)

phospho-p-Y627,Y659-GAB1 [cytosol] (Mus musculus)

phospho-p-Y627,Y659-GAB1 [cytosol] (Rattus norvegicus)

phospho-p-Y627,Y659-GAB1 [cytosol] (Sus scrofa)

phospho-p-Y627,Y659-GAB1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 627

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 659

Coordinate

659

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_997006.1, NP_002030.2

OpenTargets

ENSG00000109458

GeneCards

Q13480

PRO

Q13480

PDB

4QSY

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.95	39
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.822	9
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.796	33
UniProt:P46109 CRKL	2	p-CRKL [cytosol] (R-HSA-9024730) CRKL [cytosol] (R-HSA-354384)	0.713	4
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.609	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.609	2
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.59	25
UniProt:Q9UNN4 TF2AY			0.556	3
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.547	3
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.499	2