Reactome | CSK [plasma membrane]

CSK [plasma membrane]

Stable Identifier

R-HSA-180499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase CSK

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Locations in the PathwayBrowser for interactor 1-phosphatidyl-1D-myo-inositol

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External Reference Information

External Reference

UniProt:P41240 CSK

Gene Names

CSK

Chain

initiator methionine:1, chain:2-450

Reference Genes

BioGPS Gene:1445 CSK

COSMIC (genes):CSK CSK

CTD Gene:1445 CSK

dbSNP Gene:1445 CSK

ENSEMBL:ENSG00000103653 CSK

HGNC:2444 CSK

KEGG Gene (Homo sapiens):1445 CSK

Monarch:1445 CSK

NCBI Gene:1445 CSK

OMIM:124095 CSK

UCSC:P41240 CSK

Reference Transcript

Other Identifiers

0005570541

11724484_a_at

11724485_x_at

11740061_a_at

11751031_a_at

1445

16803059

1768_s_at

202329_at

3601851

3601852

3601853

3601854

3601855

3601856

3601859

3601861

3601862

3601865

3601867

3601868

3601870

3601871

3601873

3601875

3601876

3601877

3601878

3601880

3601881

3601883

3601884

3601885

7984871

A_23_P152024

GE59856

GO:0000166

GO:0002250

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006468

GO:0006810

GO:0007155

GO:0007165

GO:0007420

GO:0008022

GO:0008150

GO:0008283

GO:0008285

GO:0010989

GO:0015031

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0019903

GO:0030154

GO:0031295

GO:0032715

GO:0033673

GO:0034236

GO:0034330

GO:0034332

GO:0042592

GO:0042802

GO:0042997

GO:0043167

GO:0043226

GO:0043406

GO:0045121

GO:0045779

GO:0046777

GO:0046872

GO:0048709

GO:0048856

GO:0050765

GO:0050852

GO:0060368

GO:0070062

GO:0070064

GO:0070373

GO:0071375

ILMN_1754121

PH_hs_0004489

TC15000685.hg

X59932_s_at

g4758077_3p_at

Participant Of

output

Sustained activation of SRC kinase by SHP2

hasComponent

p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane]

Other forms of this molecule

CSK [cytosol]

Inferred To

csk [plasma membrane] (Danio rerio)

csk [plasma membrane] (Xenopus tropicalis)

Csk [plasma membrane] (Mus musculus)

Csk [plasma membrane] (Rattus norvegicus)

CSK [plasma membrane] (Canis familiaris)

CSK [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_004374.1, XP_005254222.1, XP_016877414.1, NP_001120662.1

ZINC - World Drugs

CSK_HUMAN

OpenTargets

ENSG00000103653

ZINC - FDA approved

CSK_HUMAN

ZINC - Substances

CSK_HUMAN

ZINC target

P41240

ZINC - Biogenic

CSK_HUMAN

PRO

P41240

PDB

3EAZ, 3D7T, 1BYG, 3D7U, 1CSK, 3EAC

ZINC - Investigational

CSK_HUMAN

HPA

ENSG00000103653-CSK

GeneCards

P41240

Ensembl

ENSP00000454906, ENST00000439220, ENST00000567571, ENSP00000220003, ENST00000220003, ENSP00000414764, ENSG00000103653

ZINC - Predictions - Purchasable

CSK_HUMAN

Orphanet

28509

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00523 SRC	9	SRC [cytosol] (R-GGA-9628701) SRC-2 [plasma membrane] (R-GGA-190535) phospho-p-Y416-SRC [cytosol] (R-GGA-8964276) MyrG-SRC [plasma membrane] (R-GGA-8876922) Src [cytosol] (R-GGA-3928468) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-2 [cytosol] (R-GGA-191648)	0.719	7
UniProt:Q9NWQ8 PAG1	2	p-Y317-PAG1 [plasma membrane] (R-HSA-180494) PAG1 [plasma membrane] (R-HSA-180500)	0.708	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.681	3
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.623	3
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.623	4
UniProt:Q63HR2 TNS2			0.597	3
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.567	8
UniProt:Q13283 G3BP1			0.556	3
UniProt:Q5T7N3 KANK4			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [azurophil granule lumen] (R-HSA-6799142) FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235)	0.527	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:Q6UWF3 SCIMP			0.499	3
ChEBI:49375 DASATINIB			0.499	2
UniProt:O15530 PDPK1	2	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210)	0.488	2
UniProt:Q8NHL6 LILRB1	1	LILRB1 [plasma membrane] (R-HSA-197721)	0.482	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

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