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Vpu mediated degradation of CD4
Stable Identifier
R-HSA-180534
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Vpu mediated degradation of CD4 (Homo sapiens)
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The HIV-1 Vpu protein promotes the degradation of the CD4 receptor by recruiting an SCF like ubiquitination complex that promotes CD4 degradation. Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4. The SKP1 component of the SCF complex is then recruited to the Vpu:beta-TrCP:CD4 promoting ubiquitination and subsequent proteasome-mediated degradation of CD4 (reviewed in Li et al., 2005). Vpu has also been shown to also increases progeny virus secretion from infected cells. Although the precise role of Vpu in this process is not yet known, it may affect ion conductive membrane pore formation and/or interference with TASK-1, an acid-sensitive K+ channel that inhibits virion release in some cells (see references in Li et al., 2005).
Literature References
PubMed ID
Title
Journal
Year
15578980
Recent advances in the understanding of HIV-1 Vpu accessory protein functions
Cohen, EA
,
Binette, J
Curr Drug Targets Immune Endocr Metabol Disord
2004
16354571
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions
Zhao, RY
,
Bukrinsky, M
,
Pauza, CD
,
Li, HS
,
Li, L
Cell Res
2005
Participants
Events
Association of Vpu with CD4
(Homo sapiens)
Vpu:CD4 associates with beta-TrCP
(Homo sapiens)
The Vpu:CD4:beta-TrCP complex recruits SKP1
(Homo sapiens)
Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
(Homo sapiens)
Degradation of ubiquitinated CD4
(Homo sapiens)
Participates
as an event of
Host Interactions of HIV factors (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2006-05-15)
Reviewed
Benarous, R (2006-09-21)
Created
Matthews, L (2006-05-23)
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