Association of APOBEC3G:Vif with the Cul5-SCF complex

Stable Identifier
R-HSA-180555
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5.

Literature References
PubMed ID Title Journal Year
14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex

Yu, X, Yu, Y, Liu, B, Luo, K, Kong, W, Mao, P, Yu, XF

Science 2003
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created