Reactome | RBX1 [cytosol]

RBX1 [cytosol]

Stable Identifier

R-HSA-180582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ROC1

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Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1

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External Reference Information

External Reference

UniProt:P62877 RBX1

Gene Names

RBX1, RNF75, ROC1

Chain

chain:1-108, initiator methionine:, chain:2-108

Reference Genes

BioGPS Gene:9978 RBX1

COSMIC (genes):RBX1 RBX1

CTD Gene:9978 RBX1

dbSNP Gene:9978 RBX1

ENSEMBL:ENSG00000100387 RBX1

ENSEMBL_homo_sapiens_GENE:ENSG00000100387.9 RBX1

HGNC:9928 RBX1

KEGG Gene (Homo sapiens):9978 RBX1

Monarch:9978 RBX1

NCBI Gene:9978 RBX1

OMIM:603814 RBX1

UCSC:P62877 RBX1

Reference Transcript

RefSeq:NM_014248.3 RBX1

Other Identifiers

11716334_a_at

11716335_x_at

16930518

218117_PM_at

218117_at

3946564

3946565

3946572

3946578

3946586

3946589

3946590

3946591

3946592

3946593

8073334

9978

A_33_P3246318

GE81903

GO:0000165

GO:0000209

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006511

GO:0006513

GO:0006974

GO:0007283

GO:0008270

GO:0016567

GO:0016740

GO:0019005

GO:0019788

GO:0022414

GO:0023052

GO:0030163

GO:0031146

GO:0031461

GO:0031462

GO:0031463

GO:0031464

GO:0031465

GO:0031466

GO:0031467

GO:0031625

GO:0032436

GO:0032480

GO:0034450

GO:0034644

GO:0036211

GO:0042110

GO:0043123

GO:0043161

GO:0043226

GO:0043687

GO:0045116

GO:0045732

GO:0046872

GO:0060090

GO:0061629

GO:0061630

GO:0061663

GO:0062197

GO:0070936

GO:0071230

GO:0090090

GO:0097602

GO:0140096

GO:0140627

GO:1902499

GO:1904263

HMNXSV003025083

PH_hs_0024230

g7657507_3p_at

Participates

as a component of

as an input of

Formation of the SCF-FBXL7 complex (Homo sapiens)

Other forms of this molecule

RBX1 [nucleoplasm]

Inferred To

rbx1 [cytosol] (Danio rerio)

rbx1 [cytosol] (Xenopus tropicalis)

RBX1 [cytosol] (Bos taurus)

RBX1 [cytosol] (Caenorhabditis elegans)

RBX1 [cytosol] (Canis familiaris)

RBX1 [cytosol] (Dictyostelium discoideum)

RBX1 [cytosol] (Drosophila melanogaster)

RBX1 [cytosol] (Gallus gallus)

RBX1 [cytosol] (Mus musculus)

RBX1 [cytosol] (Plasmodium falciparum)

RBX1 [cytosol] (Saccharomyces cerevisiae)

RBX1 [cytosol] (Schizosaccharomyces pombe)

RBX1 [cytosol] (Sus scrofa)

Rbx1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_055063.1

OpenTargets

ENSG00000100387

IntEnz

2.3.2.32

HPA

ENSG00000100387-RBX1

GeneCards

P62877

Ensembl

ENSG00000100387, ENST00000216225, ENSP00000216225

PRO

P62877

Pharos - Targets

P62877

PDB

7B5L, 6TTU, 3RTR, 8Q7H, 7B5M, 7Z8B, 8KHP, 8Q7E, 7OKQ, 8H33, 2HYE, 8B3I, 8JAQ, 7B5S, 8OR0, 8R5H, 3DQV, 8Q7R, 8JAS, 7B5N, 8OR3, 7ZBW, 1LDJ, 8H36, 8H37, 7Z8R, 1LDK, 8H34, 8H35, 8JAV, 8OR2, 8QU8, 5N4W, 8H3A, 8CDJ, 8OR4, 7ZBZ, 8CDK, 8H38, 8WQB, 8IJ1, 8H3F, 1U6G, 6R6H, 8WQA, 8WQG, 8H3R, 8WQF, 6R7F, 8WQC, 8H3Q, 8WQE, 6R7H, 7Z8T, 4P5O, 8PQL, 6R7I, 8WQH, 3DPL, 7PLO, 8GQ6, 6R7N, 4F52, 8RHZ, 8JE1, 7Z8V, 2LGV

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.978	31
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.85	9
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.823	8
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.819	7
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.754	7
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.708	10
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.666	7
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.643	3
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.643	4
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.643	3
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.643	3
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.641	3
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.623	4
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.623	4
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.611	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.528	2
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	2
UniProt:O94952 FBXO21	1	FBXO21 [cytosol] (R-HSA-8862592)	0.527	2
UniProt:Q9UK73 FEM1B	1	FEM1B [cytosol] (R-HSA-201572)	0.527	3
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.527	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.527	2
UniProt:A0A663DJA2 ORF10			0.527	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.527	3
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.527	4

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