Association of Vif with APOBEC3G

Stable Identifier
R-HSA-180602
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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The HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) .
Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.).

Literature References
PubMed ID Title Journal Year
14528301 HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

Marin, M, Rose, KM, Kozak, SL, Kabat, D

Nat Med 2003
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created