Proteosome-mediated degradation of APOBEC3G

Stable Identifier
R-HSA-180603
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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Following multi-ubiquitination by the Vif-Cul5-SCF complex, APOBEC3G is degraded by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex

Yu, X, Yu, Y, Liu, B, Luo, K, Kong, W, Mao, P, Yu, XF

Science 2003
15781449 Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function

Kobayashi, M, Takaori-Kondo, A, Miyauchi, Y, Iwai, K, Uchiyama, T

J Biol Chem 2005
14528300 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Sheehy, AM, Gaddis, NC, Malim, MH

Nat Med 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created