Reactome | VAC14 [early endosome membrane]

VAC14 [early endosome membrane]

Stable Identifier

R-HSA-1806207

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Protein VAC14 homolog, VAC14_HUMAN, ArPIKfyve, TAX1BP2, TRX

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08AM6 VAC14

Gene Names

VAC14, TAX1BP2, TRX

Chain

chain:1-782

Reference Genes

BioGPS Gene:55697 VAC14

COSMIC (genes):VAC14 VAC14

CTD Gene:55697 VAC14

dbSNP Gene:55697 VAC14

ENSEMBL:ENSG00000103043 VAC14

HGNC:25507 VAC14

KEGG:hsa:55697 VAC14

Monarch:55697 VAC14

NCBI Gene:55697 VAC14

OMIM:604632 VAC14

UCSC:Q08AM6 VAC14

Reference Transcript

RefSeq:NM_018052.3 VAC14

Other Identifiers

11719751_a_at

11719752_x_at

11750690_a_at

16827850

218169_PM_at

218169_at

3697216

3697217

3697219

3697220

3697221

3697222

3697223

3697224

3697226

3697227

3697228

3697229

3697230

3697231

3697233

3697234

3697235

3697236

3697256

3697257

3697258

3697259

3697260

3697261

3697266

3697267

3697268

3697275

3697276

3697277

3697283

3697284

3697291

3697292

3697293

3697294

3697295

3697296

3697297

3697298

3697299

3697300

3697301

3697302

3697311

3697312

55697

64468_at

8002421

8002444

86038_at

A_23_P77590

A_23_P77593

A_33_P3246283

GE55709

GE86666

GE86794

GO:0000139

GO:0005515

GO:0005768

GO:0005783

GO:0005829

GO:0006629

GO:0006661

GO:0007165

GO:0010008

GO:0016020

GO:0031410

GO:0031901

GO:0031902

GO:0038023

GO:0042802

GO:0043226

GO:0043231

GO:0060089

GO:0070772

GO:0098830

GO:0099149

HMNXSV003013007

HMNXSV003013912

HMNXSV003026341

HMNXSV003038249

ILMN_1750792

ILMN_1776092

ILMN_1799024

PH_hs_0015449

PH_hs_0026022

PH_hs_0039895

TC16001240.hg

g8922339_3p_at

g8922339_3p_x_at

Participates

as a component of

Other forms of this molecule

VAC14 [Golgi membrane]

VAC14 [late endosome membrane]

Inferred To

Vac14 [early endosome membrane] (Mus musculus)

Vac14 [early endosome membrane] (Rattus norvegicus)

VAC14 [early endosome membrane] (Bos taurus)

VAC14 [early endosome membrane] (Canis familiaris)

VAC14 [early endosome membrane] (Gallus gallus)

VAC14 [early endosome membrane] (Sus scrofa)

Cross References

RefSeq

NP_060522.3

OpenTargets

ENSG00000103043

ENSEMBL

ENST00000261776, ENST00000536184, ENSP00000261776, ENSP00000439284

HPA

ENSG00000103043-VAC14

PRO

Q08AM6

Pharos - Targets

Q08AM6

Orphanet

VAC14

GlyGen

Q08AM6

PDB

7K1Y

HMDB Protein

HMDBP14042

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.718	6
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.718	6
UniProt:Q9NUB1 ACSS1	1	ACSS1 [mitochondrial matrix] (R-HSA-449914)	0.718	6
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.718	6
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.666	4
UniProt:Q9NNX6 CD209	1	CD209 [plasma membrane] (R-HSA-2079928)	0.666	4
UniProt:Q53HV7 SMUG1	1	SMUG1 [nucleoplasm] (R-HSA-110161)	0.666	4
UniProt:P29475 NOS1	1	NOS1 [cytosol] (R-HSA-419293)	0.618	5
UniProt:O14561 NDUFAB1	4	octanoyl-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-9857608) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586)	0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.556	3
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.556	3
UniProt:P35680 HNF1B	1	HNF1B [nucleoplasm] (R-HSA-3004721)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.556	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.488	2

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