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VAC14 [Golgi membrane]
Stable Identifier
R-HSA-1806235
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Protein VAC14 homolog, VAC14_HUMAN, ArPIKfyve, TAX1BP2, TRX
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)
PIKFYVE:VAC14:FIG4 [Golgi membrane] (Homo sapiens)
VAC14 [Golgi membrane] (Homo sapiens)
PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)
PIKFYVE:VAC14:FIG4 [Golgi membrane] (Homo sapiens)
VAC14 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08AM6 VAC14
Gene Names
VAC14, TAX1BP2, TRX
Chain
chain:1-782
Reference Genes
BioGPS Gene:55697 VAC14
COSMIC (genes):VAC14 VAC14
CTD Gene:55697 VAC14
dbSNP Gene:55697 VAC14
ENSEMBL:ENSG00000103043 VAC14
ENSEMBL_homo_sapiens_GENE:ENSG00000103043.15 VAC14
HGNC:25507 VAC14
KEGG Gene (Homo sapiens):55697 VAC14
Monarch:55697 VAC14
NCBI Gene:55697 VAC14
OMIM:604632 VAC14
UCSC:Q08AM6 VAC14
Reference Transcript
RefSeq:NM_018052.3 VAC14
Other Identifiers
11719751_a_at
11719752_x_at
11750690_a_at
16827850
218169_PM_at
218169_at
3697219
3697220
3697226
3697227
3697231
3697233
3697234
3697235
3697236
3697261
3697266
3697275
3697276
3697277
3697283
3697284
3697294
3697295
3697296
3697297
3697298
3697299
3697300
3697301
3697302
3697311
3697312
55697
64468_at
8002421
A_23_P77590
GE55709
GE86666
GE86794
GO:0000139
GO:0005515
GO:0005768
GO:0005773
GO:0005783
GO:0005794
GO:0005829
GO:0006629
GO:0006661
GO:0007165
GO:0010008
GO:0016020
GO:0016192
GO:0023052
GO:0031410
GO:0031901
GO:0031902
GO:0038023
GO:0042802
GO:0043226
GO:0043231
GO:0060089
GO:0070772
GO:0098830
GO:0099149
HMNXSV003013007
HMNXSV003013912
ILMN_1750792
ILMN_1776092
ILMN_1799024
PH_hs_0026022
TC16001240.hg
g8922339_3p_at
g8922339_3p_x_at
Participates
as a component of
Pikfyve:VAC14:FIG4 [Golgi membrane] (Mus musculus)
PIKFYVE:VAC14:FIG4 [Golgi membrane] (Homo sapiens)
Other forms of this molecule
VAC14 [early endosome membrane]
VAC14 [late endosome membrane]
Inferred To
Vac14 [Golgi membrane]
(Mus musculus)
Vac14 [Golgi membrane]
(Rattus norvegicus)
VAC14 [Golgi membrane]
(Bos taurus)
VAC14 [Golgi membrane]
(Canis familiaris)
VAC14 [Golgi membrane]
(Gallus gallus)
VAC14 [Golgi membrane]
(Sus scrofa)
Cross References
RefSeq
NP_060522.3
OpenTargets
ENSG00000103043
GeneCards
Q08AM6
HPA
ENSG00000103043-VAC14
Ensembl
ENSG00000103043
,
ENSP00000261776
,
ENSP00000439284
,
ENST00000261776
,
ENST00000536184
PRO
Q08AM6
Pharos - Targets
Q08AM6
Orphanet
25848
PDB
7K1Y
HMDB Protein
HMDBP14042
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BRX5 GINS3
1
GINS3 [nucleoplasm]
(R-HSA-5688046)
0.718
6
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.718
6
UniProt:Q9NUB1 ACSS1
1
ACSS1 [mitochondrial matrix]
(R-HSA-449914)
0.718
6
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.718
6
UniProt:Q9NNX6 CD209
1
CD209 [plasma membrane]
(R-HSA-2079928)
0.666
4
UniProt:Q53HV7 SMUG1
1
SMUG1 [nucleoplasm]
(R-HSA-110161)
0.666
4
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.666
4
UniProt:P29475 NOS1
1
NOS1 [cytosol]
(R-HSA-419293)
0.618
5
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.556
3
UniProt:O14561 NDUFAB1
4
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
0.556
3
UniProt:O95231 VENTX
1
VENTX [nucleoplasm]
(R-HSA-8853887)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P35680 HNF1B
1
HNF1B [nucleoplasm]
(R-HSA-3004721)
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.556
3
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.488
2
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