Interaction of Vpr with importin alpha

Stable Identifier
R-HSA-180627
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Vpr interacts with importin-alpha through alphaH1 and alphaH2. The interaction via alphaH1 is indispensable for the nuclear entry of Vpr (Kamata et al., 2005) .
Literature References
PubMed ID Title Journal Year
9436978 HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

Vodicka, MA, Emerman, M, Koepp, DM, Silver, PA

Genes Dev 1998
9582382 Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex

Blobel, G, Bukrinsky, M, Rexach, M, Popov, S, Ratner, L

J Biol Chem 1998
15731250 Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr

Nitahara-Kasahara, Y, Yoneda, Y, Kamata, M, Miyamoto, Y, Aida, Y

J Virol 2005
Participants
Participates
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Reviewed
Created
Cite Us!