Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand

Stable Identifier
R-HSA-180634
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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In the target cell, HIV-1-associated APOBEC3G binds to the HIV-1 reverse transcript minus strand and catalyzes the deamination of cytidines in a specific dinucleotide context (e.g., dCC). In contrast, APOBEC3F and APOBEC3B display a preference for dTC.

Literature References
PubMed ID Title Journal Year
15098018 Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

Yu, Q, Konig, R, Pillai, S, Chiles, K, Kearney, M, Palmer, S, Richman, D, Coffin, JM, Landau, NR

Nat Struct Mol Biol 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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