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Nuclear import of Rev protein
Stable Identifier
R-HSA-180746
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Interactions of Rev with host cellular proteins (Homo sapiens)
Nuclear import of Rev protein (Homo sapiens)
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Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin beta-B23 complex associates with the nuclear pore through interactions between importin beta and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin beta resulting in in the disassembly of the importin beta-Rev-B23 complex and the release of Rev cargo.
Participants
Events
Association of multimerized Rev with beta-importin
(Homo sapiens)
Rev associates with B23
(Homo sapiens)
Rev:importin beta:B23 recruited to the nuclear pore
(Homo sapiens)
Translocation of Rev:importin-beta:B23 to the nucleus
(Homo sapiens)
Conversion of Ran-GDP to Ran-GTP
(Homo sapiens)
Association of Ran-GTP with importin-beta
(Homo sapiens)
Disassembly of the Rev-importin beta-B23:Ran-GTP complex
(Homo sapiens)
Participates
as an event of
Interactions of Rev with host cellular proteins (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2006-06-08)
Reviewed
Kumar, A (2007-02-01)
Created
Matthews, L (2006-06-02)
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