Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization

Stable Identifier
R-HSA-180897
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
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In one model of Vpr mediated induction of apoptosis, Vpr acts directly on the mitochondrial permeability transition pore complex through its interaction with adenine nucleotide translocator (ANT). This interaction promotes the permeabiliztion of the mitochondrial membranes resulting in the release of cytochrome c and apoptosis-inducing factors.

Literature References
PubMed ID Title Journal Year
10620603 The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

Jacotot, E, Ravagnan, L, Loeffler, M, Ferri, KF, Vieira, HL, Zamzami, N, Costantini, P, Druillennec, S, Hoebeke, J, Briand, JP, Irinopoulou, T, Daugas, E, Susin, SA, Cointe, D, Xie, ZH, Reed, JC, Roques, BP, Kroemer, G

J Exp Med 2000
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created