Association of Vpr with ANT1

Stable Identifier
R-HSA-180905
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space
ReviewStatus
5/5
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Association of Vpr with ANT1
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Vpr interacts with the PTPC component ANT1. This interaction induces mitochondrial membrane permeabilization and release of cytochrome c and apoptotic factors.
Literature References
PubMed ID Title Journal Year
10620603 The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

Briand, JP, Cointe, D, Daugas, E, Costantini, P, Vieira, HL, Druillennec, S, Reed, JC, Kroemer, G, Loeffler, M, Roques, BP, Hoebeke, J, Ravagnan, L, Susin, SA, Irinopoulou, T, Xie, ZH, Jacotot, E, Ferri, KF, Zamzami, N

J Exp Med 2000
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2006-05-15)
Reviewed
Zhao, RY  (2006-07-12)
Created
Matthews, L  (2006-06-08)
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