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MyrG-p-Y426-YES1 [plasma membrane]
Stable Identifier
R-HSA-1810411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Y426-N-myristoyl-YES1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
SRC,YES1 bind YAP1 (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane] (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
SRC,YES1 phosphorylate YAP1 (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1:YAP1 [plasma membrane] (Homo sapiens)
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
SRC family kinases phosphorylate ERBB2 (Homo sapiens)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Homo sapiens)
MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07947 YES1
Gene Names
YES1, YES
Chain
initiator methionine:1, chain:2-543
Reference Genes
BioGPS Gene:7525 YES1
COSMIC (genes):YES1 YES1
CTD Gene:7525 YES1
dbSNP Gene:7525 YES1
ENSEMBL:ENSG00000176105 YES1
HGNC:12841 YES1
KEGG Gene (Homo sapiens):7525 YES1
Monarch:7525 YES1
NCBI Gene:7525 YES1
OMIM:164880 YES1
UCSC:P07947 YES1
Reference Transcript
RefSeq:XM_017025960.1 YES1
RefSeq:NM_005433.3 YES1
Other Identifiers
0006510079
11719415_a_at
1674_at
16853445
202932_at
202933_s_at
2521765
3795939
3795941
3795943
3795944
3795945
3795946
3795950
3795952
3795954
3795958
3795959
3795962
3795965
3795966
3795967
3795970
3795971
3795990
3795991
3795992
3795993
3795994
3795995
3795996
3940656
3940657
3940661
7525
8021984
A_23_P164507
A_24_P48403
GE62489
GO:0000166
GO:0001784
GO:0002376
GO:0003013
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005154
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007155
GO:0007165
GO:0007169
GO:0008150
GO:0008283
GO:0009058
GO:0010827
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0030154
GO:0031234
GO:0031295
GO:0034641
GO:0036120
GO:0038083
GO:0038096
GO:0040011
GO:0042127
GO:0043114
GO:0043167
GO:0043226
GO:0044325
GO:0045087
GO:0045944
GO:0046777
GO:0048013
GO:0048870
GO:0050731
GO:0050900
GO:0055085
GO:0070062
GO:0071300
GO:0071560
GO:0098978
GO:0099091
ILMN_1691466
M15990_at
PH_hs_0035676
TC18000278.hg
g4885660_3p_a_at
Participant Of
hasMember
MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane]
hasCandidate
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]
Other forms of this molecule
YES1 [cytosol]
Inferred To
phospho-yes1 [plasma membrane] (Danio rerio)
phospho-yes1 [plasma membrane] (Xenopus tropicalis)
phospho-YES1 [plasma membrane] (Bos taurus)
phospho-YES1 [plasma membrane] (Gallus gallus)
phospho-YES1 [plasma membrane] (Sus scrofa)
phospho-Yes1 [plasma membrane] (Mus musculus)
phospho-Yes1 [plasma membrane] (Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 426
Coordinate
426
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
XP_016881449.1
,
NP_005424.1
ZINC - World Drugs
YES_HUMAN
OpenTargets
ENSG00000176105
ZINC - FDA approved
YES_HUMAN
ZINC - Substances
YES_HUMAN
ZINC target
P07947
ZINC - Biogenic
YES_HUMAN
PRO
P07947
PDB
2HDA
ZINC - Investigational
YES_HUMAN
GeneCards
P07947
HPA
ENSG00000176105-YES1
Ensembl
ENSP00000462468
,
ENSG00000176105
,
ENSP00000324740
,
ENST00000584307
,
ENST00000314574
ZINC - Predictions - Purchasable
YES_HUMAN
HMDB Protein
HMDBP01230
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.718
6
UniProt:O14543 SOCS3
1
SOCS3 [cytosol]
(R-HSA-873794)
0.718
6
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.718
6
UniProt:Q8IVP5 FUNDC1
4
p-S13,Y18-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934915)
p-S17-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8948140)
FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934922)
p-S13-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934910)
0.666
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.564
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:P14136 GFAP
3
GFAP [lysosomal membrane]
(R-HSA-9625195)
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.556
3
UniProt:P56945 BCAR1
4
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:O60496 DOK2
1
DOK2 [cytosol]
(R-HSA-204823)
0.556
3
UniProt:O14508 SOCS2
1
SOCS2 [cytosol]
(R-HSA-1169204)
0.556
3
UniProt:P46109 CRKL
2
p-CRKL [cytosol]
(R-HSA-9024730)
CRKL [cytosol]
(R-HSA-354384)
0.556
3
UniProt:P09769 FGR
3
FGR [secretory granule lumen]
(R-HSA-6804974)
FGR [cytosol]
(R-HSA-432116)
FGR [extracellular region]
(R-HSA-6806524)
0.527
3
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