Reactome | MyrG-p-Y426-YES1 [plasma membrane]

MyrG-p-Y426-YES1 [plasma membrane]

Stable Identifier

R-HSA-1810411

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y426-N-myristoyl-YES1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07947 YES1

Gene Names

YES1, YES

Chain

initiator methionine:1, chain:2-543

Reference Genes

BioGPS Gene:7525 YES1

COSMIC (genes):YES1 YES1

CTD Gene:7525 YES1

dbSNP Gene:7525 YES1

ENSEMBL:ENSG00000176105 YES1

HGNC:12841 YES1

KEGG Gene (Homo sapiens):7525 YES1

Monarch:7525 YES1

NCBI Gene:7525 YES1

OMIM:164880 YES1

UCSC:P07947 YES1

Reference Transcript

Other Identifiers

0006510079

11719415_a_at

1674_at

16853445

202932_at

202933_s_at

2521765

3795939

3795941

3795943

3795944

3795945

3795946

3795950

3795952

3795954

3795958

3795959

3795962

3795965

3795966

3795967

3795970

3795971

3795990

3795991

3795992

3795993

3795994

3795995

3795996

3940656

3940657

3940661

7525

8021984

A_23_P164507

A_24_P48403

GE62489

GO:0000166

GO:0001784

GO:0002376

GO:0002862

GO:0003013

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004715

GO:0005102

GO:0005154

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007169

GO:0008150

GO:0009058

GO:0010827

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0030154

GO:0031234

GO:0031295

GO:0034641

GO:0036120

GO:0038096

GO:0040011

GO:0043114

GO:0043167

GO:0043226

GO:0044325

GO:0045087

GO:0045944

GO:0046777

GO:0048013

GO:0048870

GO:0050731

GO:0050900

GO:0055085

GO:0070062

GO:0071300

GO:0071560

GO:0098978

GO:0099091

HMNXSV003042499

ILMN_1691466

M15990_at

PH_hs_0035676

TC18000278.hg

g4885660_3p_a_at

Participates

as a member of

MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)

as a candidate of

p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

YES1 [cytosol]

Inferred To

phospho-yes1 [plasma membrane] (Danio rerio)

phospho-YES1 [plasma membrane] (Bos taurus)

phospho-YES1 [plasma membrane] (Gallus gallus)

phospho-src-1 [plasma membrane] (Caenorhabditis elegans)

phospho-Yes1 [plasma membrane] (Mus musculus)

phospho-Yes1 [plasma membrane] (Rattus norvegicus)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 426

Coordinate

426

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

XP_016881449.1, NP_005424.1

ZINC - World Drugs

YES_HUMAN

Guide to Pharmacology - Targets

2284

OpenTargets

ENSG00000176105

ZINC - FDA approved

YES_HUMAN

ZINC - Substances

YES_HUMAN

ZINC - Biogenic

YES_HUMAN

ZINC target

P07947

PRO

P07947

GlyGen

P07947

PDB

2HDA

ZINC - Investigational

YES_HUMAN

GeneCards

P07947

HPA

ENSG00000176105-YES1

Ensembl

ENST00000584307, ENSG00000176105, ENSP00000324740, ENSP00000462468, ENST00000314574

Pharos - Targets

P07947

ZINC - Predictions - Purchasable

YES_HUMAN

HMDB Protein

HMDBP01230

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366)	0.718	6
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [cytosol] (R-HSA-66370)	0.718	6
UniProt:Q8IVP5 FUNDC1	4	FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.564	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:P56945 BCAR1	4	p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.556	3
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	6
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.527	3

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