Reactome | MyrG-p-Y426-YES1 [plasma membrane]

MyrG-p-Y426-YES1 [plasma membrane]

Stable Identifier

R-HSA-1810411

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y426-N-myristoyl-YES1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07947 YES1

Gene Names

YES1, YES

Chain

initiator methionine:1, chain:2-543

Reference Genes

BioGPS Gene:7525 YES1

COSMIC (genes):YES1 YES1

CTD Gene:7525 YES1

dbSNP Gene:7525 YES1

ENSEMBL:ENSG00000176105.14 YES1

HGNC:12841 YES1

KEGG Gene (Homo sapiens):7525 YES1

Monarch:7525 YES1

NCBI Gene:7525 YES1

OMIM:164880 YES1

UCSC:P07947 YES1

Reference Transcript

Other Identifiers

0006510079

11719415_a_at

1674_at

16853445

202932_PM_at

202932_at

202933_PM_s_at

202933_s_at

2521765

3795939

3795941

3795943

3795944

3795945

3795946

3795950

3795952

3795954

3795958

3795959

3795962

3795965

3795966

3795967

3795970

3795971

3795990

3795991

3795992

3795993

3795994

3795995

3795996

3940656

3940657

3940661

7525

8021984

A_23_P164507

A_24_P48403

GE62489

GO:0000166

GO:0001784

GO:0002376

GO:0002862

GO:0003013

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0006954

GO:0007155

GO:0007169

GO:0010827

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019899

GO:0023052

GO:0030154

GO:0031234

GO:0031295

GO:0036120

GO:0036211

GO:0038096

GO:0043114

GO:0043226

GO:0044325

GO:0045087

GO:0045944

GO:0048013

GO:0048870

GO:0050731

GO:0050900

GO:0055085

GO:0070062

GO:0071300

GO:0071560

GO:0098542

GO:0140096

HMNXSV003042499

ILMN_1691466

M15990_at

PH_hs_0035676

TC18000278.hg

g4885660_3p_a_at

Participates

as a member of

MyrG-p-Y419-SRC,MyrG-p-Y426-YES1 [plasma membrane] (Homo sapiens)

as a candidate of

p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

YES1 [cytosol]

Inferred To

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Bos taurus)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Caenorhabditis elegans)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Canis familiaris)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Danio rerio)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Drosophila melanogaster)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Gallus gallus)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Mus musculus)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Rattus norvegicus)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Sus scrofa)

phospho-MyrG-p-Y426-YES1 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 426

Coordinate

426

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

NP_005424.1, XP_016881449.1

ZINC - World Drugs

YES_HUMAN

Guide to Pharmacology - Targets

2284

OpenTargets

ENSG00000176105

ZINC - FDA approved

YES_HUMAN

ZINC - Substances

YES_HUMAN

ZINC target

P07947

ZINC - Biogenic

YES_HUMAN

PRO

P07947

PDB

2HDA

ZINC - Investigational

YES_HUMAN

GeneCards

P07947

HPA

ENSG00000176105-YES1

Ensembl

ENSP00000462468, ENSP00000324740, ENSG00000176105, ENST00000584307, ENST00000314574

Pharos - Targets

P07947

ZINC - Predictions - Purchasable

YES_HUMAN

HMDB Protein

HMDBP01230

Interactors (64)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BWW4 SSBP3			0.718	6
UniProt:Q9NVV9 THAP1			0.718	6
UniProt:Q96BR9 ZBT8A			0.718	6
UniProt:I6L996 I6L996			0.718	6
UniProt:P51116 FXR2			0.718	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272)	0.718	6
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.718	6
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.718	6
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.683	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.669	4
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.571	2
UniProt:Q8TAK6 OLIG1			0.57	3
UniProt:Q9H5V8 CDCP1			0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.556	3
UniProt:Q9NUP9 LIN7C	2	LIN7C [transport vesicle membrane] (R-HSA-9610411) LIN7C [plasma membrane] (R-HSA-5216165)	0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:P49023-2 PXN			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q68D51-2 DENND2C			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	3
UniProt:Q9Y592-2 CEP83			0.556	3
UniProt:O43281-2 EFS			0.556	5
UniProt:O14512 SOCS7			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	5
UniProt:Q8IYX8 CE57L			0.556	3
UniProt:Q96GY0 ZC21A			0.556	3
UniProt:Q9ULV8 CBLC			0.556	3
UniProt:Q9C035-3 TRIM5			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q16630-2 CPSF6	1	CPSF6-2 [nucleoplasm] (R-HSA-72014)	0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q9UGK3 STAP2	2	p-Y250-STAP2 [plasma membrane] (R-HSA-8848079) STAP2 [cytosol] (R-HSA-8848028)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.556	3
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q58FF7 H90B3			0.527	3
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	6
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [cytosol] (R-HSA-432116) FGR [secretory granule lumen] (R-HSA-6804974)	0.527	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.524	2
UniProt:P25445-1 FAS			0.499	2
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.488	2
UniProt:Q08345-1 DDR1			0.462	7

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