Toll Like Receptor 2 (TLR2) Cascade

Stable Identifier
R-HSA-181438
Type
Pathway
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
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TLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at least some other TLR2 ligands may be assisted by additional accessory proteins, particularly in association with TLR1 or TLR6. TLR2 is expressed constitutively on macrophages, dendritic cells, and B cells, and can be induced in some other cell types, including epithelial cells. TLR1 and TLR6, on the other hand, are expressed almost ubiquitously (Muzio et al. 2000). TLR2 may be a sensor and inductor of specific defense processes, including oxidative stress and cellular necrosis initially spurred by microbial compounds.

Literature References
PubMed ID Title Journal Year
10820283 Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

Muzio, M, Bosisio, D, Polentarutti, N, D'amico, G, Stoppacciaro, A, Mancinelli, R, van't Veer, C, Penton-Rol, G, Ruco, LP, Allavena, P, Mantovani, A

J Immunol 2000
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Participant Of
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Orthologous Events
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Reviewed
Created