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VAMP2 [synaptic vesicle membrane]
Stable Identifier
R-HSA-181517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
synaptic vesicle membrane
Locations in the PathwayBrowser for interactor UniProt:P61266 STX1B
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type B (BoNT/B) (Homo sapiens)
BoNT/B LC cleaves target cell VAMP2 (Homo sapiens)
VAMP2 [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type D (BoNT/D) (Homo sapiens)
BoNT/D LC cleaves target cell VAMP2 (Homo sapiens)
VAMP2 [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type F (BoNT/F) (Homo sapiens)
BoNT/F LC cleaves target cell VAMP2 (Homo sapiens)
VAMP2 [synaptic vesicle membrane] (Homo sapiens)
Toxicity of botulinum toxin type G (BoNT/G) (Homo sapiens)
BoNT/G LC cleaves target cell VAMP2 (Homo sapiens)
VAMP2 [synaptic vesicle membrane] (Homo sapiens)
Toxicity of tetanus toxin (TeNT) (Homo sapiens)
TeNT LC cleaves target cell VAMP2 (Homo sapiens)
VAMP2 [synaptic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63027 VAMP2
Gene Names
VAMP2, SYB2
Chain
initiator methionine:1, chain:2-116
Reference Genes
BioGPS Gene:6844 VAMP2
COSMIC (genes):VAMP2 VAMP2
CTD Gene:6844 VAMP2
dbSNP Gene:6844 VAMP2
ENSEMBL:ENSG00000220205 VAMP2
HGNC:12643 VAMP2
KEGG Gene (Homo sapiens):6844 VAMP2
Monarch:6844 VAMP2
NCBI Gene:6844 VAMP2
OMIM:185881 VAMP2
UCSC:P63027 VAMP2
Reference Transcript
RefSeq:NM_014232.2 VAMP2
Other Identifiers
0002810167
11716067_at
11716068_a_at
16840876
201556_s_at
201557_at
214792_x_at
32254_at
3744218
3744219
3744221
3744222
3744223
3744227
3FIE
3FII
3RK2
3RK3
3RL0
6844
78785
8012376
A_23_P164341
A_24_P313576
A_33_P3213493
A_33_P3409886
AAA60604
AAF15551
AAH02737
AAH19608
AAH33870
AF135372
AJ225044
AK289555
BAF82244
BC002737
BC019608
BC033870
CAA12385
CAB078785
CCDS32561
CH471108
EAW90087
ENSG00000220205
ENSP00000314214
ENST00000316509
ENST00000316509.10
EntrezGene:6844
EntrezGene:VAMP2
F8WCA0
g12803794_3p_a_at
g12803794_3p_x_at
g7657674_3p_at
g7657674_3p_x_at
GE62982
GO:0000149
GO:0002376
GO:0003674
GO:0005515
GO:0005516
GO:0005543
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005886
GO:0005887
GO:0006810
GO:0006887
GO:0006892
GO:0007267
GO:0007269
GO:0008021
GO:0008076
GO:0008150
GO:0008289
GO:0009749
GO:0014047
GO:0015031
GO:0016020
GO:0016021
GO:0016079
GO:0016192
GO:0017075
GO:0017156
GO:0017157
GO:0019905
GO:0022607
GO:0030054
GO:0030136
GO:0030141
GO:0030665
GO:0030667
GO:0030672
GO:0031201
GO:0031410
GO:0031982
GO:0032869
GO:0032991
GO:0042589
GO:0043001
GO:0043005
GO:0043167
GO:0043226
GO:0043231
GO:0043308
GO:0043621
GO:0044306
GO:0045202
GO:0048306
GO:0048471
GO:0055085
GO:0060203
GO:0060291
GO:0060627
GO:0061024
GO:0061025
GO:0061202
GO:0065003
GO:0070032
GO:0070033
GO:0070044
GO:0070083
GO:0090316
GO:1902259
HGNC:12643
Hs.194534.1.A1_3p_a_at
Hs.194534.1.A1_3p_x_at
ILMN_1699044
ILMN_1713491
ILMN_1911044
IPR001388
IPR016444
IPR028717
J3QRU4
K7ENK9
M36201
M36202
M36203
M36204
M36205
M36205_at
MIM:185881
NM_014232
NP_055047
PF00957
PH_hs_0002231
PR00219
TC17002850.hg
UPI00000527F8
VAMP2
VAMP2-201
Participant Of
input
BoNT/B LC cleaves target cell VAMP2
BoNT/D LC cleaves target cell VAMP2
BoNT/F LC cleaves target cell VAMP2
BoNT/G LC cleaves target cell VAMP2
TeNT LC cleaves target cell VAMP2
Other forms of this molecule
VAMP2 [plasma membrane]
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
VAMP2(59-116) [synaptic vesicle membrane]
VAMP2(2-58) [cytosol]
VAMP2(2-76) [cytosol]
VAMP2(77-116) [synaptic vesicle membrane]
VAMP2(60-116) [synaptic vesicle membrane]
VAMP2(2-59) [cytosol]
VAMP2(82-116) [synaptic vesicle membrane]
VAMP2(2-81) [cytosol]
VAMP2 [secretory granule membrane]
VAMP2 [cytosol]
VAMP2 [endoplasmic reticulum membrane]
VAMP2 [cytoplasmic vesicle membrane]
VAMP2 [lysosomal membrane]
VAMP2 [Golgi membrane]
VAMP2 [cytoplasmic vesicle membrane]
VAMP2 [secretory granule membrane]
VAMP2 [clathrin-coated endocytic vesicle membrane]
Cross References
RefSeq
NP_055047.2
OpenTargets
ENSG00000220205
GeneCards
P63027
PRO
P63027
PDB
3RK3
,
3FII
,
3RK2
,
3RL0
,
3FIE
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60880-2 SNAP25
0.764
9
UniProt:O95721 SNAP29
3
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
0.696
5
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.696
5
UniProt:O14810 CPLX1
1
CPLX1 [cytosol]
(R-HSA-210385)
0.656
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.632
5
UniProt:Q16623 STX1A
6
STX1A [plasma membrane]
(R-HSA-6794231)
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.621
4
UniProt:O94806 PRKD3
1
PRKD3 [cytosol]
(R-HSA-58212)
0.618
7
UniProt:O55012
3
PICALM [Golgi membrane]
(R-RNO-434341)
PICALM [cytosol]
(R-RNO-8867593)
PICALM [cytoplasmic vesicle membrane]
(R-RNO-429812)
0.558
2
UniProt:Q57236 Q57236
0.558
3
UniProt:Q8TBB6 S7A14
0.488
2
UniProt:P61266 STX1B
3
STX1B(?-288) [plasma membrane]
(R-HSA-5246519)
STX1B(1-?) [cytosol]
(R-HSA-5246520)
STX1B [plasma membrane]
(R-HSA-181479)
0.488
2
UniProt:Q9Y282 ERGI3
0.488
2
UniProt:Q96BA8 CREB3L1
7
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.488
2
IntAct:EBI-12003048 TMEM31
0.488
2
UniProt:Q3SXY8 ARL13B
2
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
0.488
2
UniProt:P31937 HIBADH
1
HIBADH [mitochondrial matrix]
(R-HSA-70882)
0.488
2
UniProt:Q8N5M9 JAGN1
0.488
2
UniProt:P32856-2 STX2
0.488
2
UniProt:Q8N6L0 KASH5
0.488
2
UniProt:Q8IWU4 SLC30A8
1
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.488
2
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.488
2
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