Reactome: A Curated Pathway Database

HIST1H4

Stable Identifier
R-HSA-181902
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Histone H4, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
Chain
initiator methionine:1, chain:2-103
Reference Genes
ENSEMBL:ENSG00000274618 HIST1H4A, ENSEMBL:ENSG00000270882 HIST1H4A, ENSEMBL:ENSG00000275126 HIST1H4A, ENSEMBL:ENSG00000197238 HIST1H4A, BioGPS Gene:554313 HIST1H4A, ENSEMBL:ENSG00000276966 HIST1H4A, CTD Gene:554313 HIST1H4A, ENSEMBL:ENSG00000276180 HIST1H4A, ENSEMBL:ENSG00000158406 HIST1H4A, NCBI Gene:554313 HIST1H4A, ENSEMBL:ENSG00000278705 HIST1H4A, dbSNP Gene:554313 HIST1H4A, Monarch:554313 HIST1H4A, ENSEMBL:ENSG00000197061 HIST1H4A, NCBI Gene:8294 HIST1H4A, ENSEMBL:ENSG00000197837 HIST1H4A, ENSEMBL:ENSG00000273542 HIST1H4A, dbSNP Gene:8294 HIST1H4A, NCBI Gene:8367 HIST1H4A, Monarch:8294 HIST1H4A, BioGPS Gene:8294 HIST1H4A, CTD Gene:8294 HIST1H4A, dbSNP Gene:8367 HIST1H4A, Monarch:8367 HIST1H4A, BioGPS Gene:8367 HIST1H4A, CTD Gene:8367 HIST1H4A, ENSEMBL:ENSG00000270276 HIST1H4A, ENSEMBL:ENSG00000277157 HIST1H4A, ENSEMBL:ENSG00000278637 HIST1H4A, BioGPS Gene:8368 HIST1H4A, CTD Gene:8368 HIST1H4A, NCBI Gene:8368 HIST1H4A, CTD Gene:8366 HIST1H4A, BioGPS Gene:121504 HIST1H4A, dbSNP Gene:8366 HIST1H4A, CTD Gene:121504 HIST1H4A, NCBI Gene:8366 HIST1H4A, BioGPS Gene:8366 HIST1H4A, NCBI Gene:121504 HIST1H4A, Monarch:8366 HIST1H4A, dbSNP Gene:121504 HIST1H4A, Monarch:121504 HIST1H4A, HGNC:4783 HIST1H4A, HGNC:4788 HIST1H4A, NCBI Gene:8365 HIST1H4A, HGNC:4793 HIST1H4A, HGNC:4785 HIST1H4A, HGNC:4784 HIST1H4A, dbSNP Gene:8365 HIST1H4A, HGNC:4791 HIST1H4A, Monarch:8365 HIST1H4A, HGNC:4794 HIST1H4A, BioGPS Gene:8365 HIST1H4A, HGNC:29607 HIST1H4A, CTD Gene:8365 HIST1H4A, HGNC:20510 HIST1H4A, COSMIC (genes):HIST1H4A HIST1H4A, CTD Gene:8364 HIST1H4A, dbSNP Gene:8364 HIST1H4A, NCBI Gene:8364 HIST1H4A, BioGPS Gene:8364 HIST1H4A, Monarch:8364 HIST1H4A, KEGG Gene (Homo sapiens):HIST1H4I HIST1H4A, KEGG Gene (Homo sapiens):HIST2H4B HIST1H4A, KEGG Gene (Homo sapiens):HIST4H4 HIST1H4A, HGNC:4781 HIST1H4A, HGNC:4789 HIST1H4A, HGNC:4787 HIST1H4A, HGNC:4782 HIST1H4A, HGNC:4790 HIST1H4A, NCBI Gene:8362 HIST1H4A, BioGPS Gene:8362 HIST1H4A, OMIM:602829 HIST1H4A, Monarch:8362 HIST1H4A, KEGG Gene (Homo sapiens):8367 HIST1H4A, CTD Gene:8362 HIST1H4A, dbSNP Gene:8362 HIST1H4A, OMIM:602828 HIST1H4A, CTD Gene:8363 HIST1H4A, CTD Gene:8370 HIST1H4A, BioGPS Gene:8370 HIST1H4A, Monarch:8370 HIST1H4A, KEGG Gene (Homo sapiens):8294 HIST1H4A, dbSNP Gene:8370 HIST1H4A, CTD Gene:8360 HIST1H4A, OMIM:142750 HIST1H4A, BioGPS Gene:8360 HIST1H4A, Monarch:8360 HIST1H4A, NCBI Gene:8370 HIST1H4A, dbSNP Gene:8360 HIST1H4A, NCBI Gene:8360 HIST1H4A, OMIM:602822 HIST1H4A, KEGG Gene (Homo sapiens):554313 HIST1H4A, Monarch:8359 HIST1H4A, OMIM:602823 HIST1H4A, BioGPS Gene:8359 HIST1H4A, NCBI Gene:8359 HIST1H4A, dbSNP Gene:8359 HIST1H4A, CTD Gene:8359 HIST1H4A, KEGG Gene (Homo sapiens):121504 HIST1H4A, OMIM:602824 HIST1H4A, Monarch:8368 HIST1H4A, dbSNP Gene:8368 HIST1H4A, KEGG Gene (Homo sapiens):8362 HIST1H4A, KEGG Gene (Homo sapiens):8361 HIST1H4A, KEGG Gene (Homo sapiens):8360 HIST1H4A, KEGG Gene (Homo sapiens):8359 HIST1H4A, KEGG Gene (Homo sapiens):8366 HIST1H4A, OMIM:602830 HIST1H4A, OMIM:602831 HIST1H4A, KEGG Gene (Homo sapiens):8365 HIST1H4A, dbSNP Gene:8361 HIST1H4A, CTD Gene:8361 HIST1H4A, Monarch:8361 HIST1H4A, OMIM:602833 HIST1H4A, BioGPS Gene:8361 HIST1H4A, KEGG Gene (Homo sapiens):8364 HIST1H4A, NCBI Gene:8361 HIST1H4A, OMIM:615069 HIST1H4A, KEGG Gene (Homo sapiens):8363 HIST1H4A, OMIM:602825 HIST1H4A, OMIM:602826 HIST1H4A, KEGG Gene (Homo sapiens):8370 HIST1H4A, Monarch:8363 HIST1H4A, OMIM:602827 HIST1H4A, BioGPS Gene:8363 HIST1H4A, NCBI Gene:8363 HIST1H4A, KEGG Gene (Homo sapiens):8368 HIST1H4A, dbSNP Gene:8363 HIST1H4A
Reference Transcript
Other Identifiers
 0001050411  0002190092  0002760136  0003140609  0003520324
 0003610035  0003800215  0004010551  0004120750  0004570465
 0005570082  0005570184  0006110717  0006620279  11503
 11715116_s_at  11726245_s_at  11726246_x_at  11728049_s_at  11733368_at
 11733369_x_at  11733426_at  11735753_at  11735775_at  11735776_x_at
 11735942_at  11737314_at  11738060_s_at  11738103_at  11738601_at
 11741794_s_at  11742669_s_at  11759221_at  121504  152_f_at
 16670377  16692626  16761778  17005560  17005586
 17005596  17005868  17016360  17016383  17016406
 17016494  17016503  17016506  1ZKK  205967_at
 206951_at  207046_at  208026_at  208046_at  208076_at
 208180_s_at  208580_x_at  214463_x_at  214509_at  214516_at
 214562_at  21887  232035_at  2357896  2357897
 2357898  2357899  2357900  2357901  2357902
 2357906  2434103  2434105  2434106  2434107
 2434108  2434109  2434110  2434111  2899096
 2899097  2899145  2899147  2899148  2899149
 2899217  2899218  2899219  2899220  2899244
 2899245  2899246  2899247  2899248  2899769
 2899770  2899771  2900063  2900064  2900065
 2946209  2946210  2946211  2946212  2946213
 2946214  2946318  2946320  2946321  2946379
 2946380  2946384  2946387  2946388  2946389
 2947057  2947058  2947059  2947078  2947079
 2947080  2947082  2947083  2947084  2BQZ
 2CV5  2IG0  2KWN  2KWO  2LVM
 2QQS  2RJE  2RNY  2RS9  31521_f_at
 31751_f_at  33018_at  33049_at  34027_f_at  3445648
 3445649  3445653  3445654  3445655  3445656
 37279  39969_at  3A6N  3AFA  3AN2
 3AV1  3AV2  3AYW  3AZE  3AZF
 3AZG  3AZH  3AZI  3AZJ  3AZK
 3AZL  3AZM  3AZN  3CFS  3CFV
 3F9W  3F9X  3F9Y  3F9Z  3IJ1
 3JPX  3NQJ  3NQU  3O36  3QBY
 3QZS  3QZT  3QZV  3R45  3UVW
 3UVX  3UVY  3UW9  3W96  3W97
 3W98  3W99  3WA9  3WAA  3WKJ
 3WTP  3X1S  3X1T  3X1U  3X1V
 42201  4GQB  4H9N  4H9O  4H9P
 4H9Q  4H9R  4H9S  4HGA  4M38
 4N3W  4N4F  4QUT  4QUU  4QYD
 4U9W  4YM5  4YM6  4YY6  4YYD
 4YYG  4YYH  4YYI  4YYJ  4YYK
 4YYM  4YYN  4Z2M  4Z5T  554313
 57785_at  59154_at  5AV5  5AV6  5AV8
 5AV9  5AVB  5AVC  5AY8  5B0Y
 5B0Z  5B24  5B2I  5B2J  5B31
 5B32  5B33  5B40  5BNV  5BNX
 5BO0  5C3I  5CPI  5CPJ  5CPK
 5FA5  5FFW  5FWE  5GSU  5GT0
 5GT3  5GXQ  5JA4  5JRG  5KDM
 5TEG  5X7X  762_f_at  7905067  7919627
 7961483  81125_at  8117334  8117368  8117402
 8117422  8117537  8117598  8124385  8124413
 8124448  8124521  8124531  8124534  8180255
 8180321  82468_at  8294  8359  8360
 8361  8362  8363  8364  8365
 8366  8367  8368  8370  A_14_P107645
 A_14_P121153  A_14_P137590  A_21_P0014172  A_23_P156609  A_23_P214487
 A_23_P30805  A_23_P30813  A_23_P323685  A_23_P359540  A_23_P388871
 A_23_P395374  A_23_P415411  A_23_P431179  A_23_P436281  A_23_P70480
 A_24_P166407  A_24_P20873  A_24_P261691  A_24_P9321  A_33_P3299865
 A_33_P3344229  A_33_P3351851  A_33_P3378880  A_33_P3410836  AAA52652
 AAA63188  AAH17361  AAH54014  AAH66248  AAH66249
 AAH66250  AAH67495  AAH67496  AAH67497  AAH69288
 AAH69392  AAH69467  AAH69654  AAH93763  AAH93765
 AAH93969  AAI11094  AAI11435  AAI12194  AAI20940
 AAI28105  AAI28106  AAI30559  AAI30561  AAI43046
 AAI48272  AAM83108  AAN01438  AAN01439  AAN01440
 AAN01441  AAN01442  AAN01443  AAN01444  AAN01446
 AAN01447  AAN01448  AAN01449  AAN01450  AAT68253
 AB000905  AB000905_at  AB451459  ADDON000875.hg  ADDON001483.hg
 ADDON002748.hg  ADDON002749.hg  ADDON002750.hg  ADDON002752.hg  ADDON002753.hg
 ADDON002754.hg  ADDON002776.hg  ADDON002784.hg  ADDON002794.hg  ADDON002882.hg
 AF525682  AK311916  AK312028  AK312153  AK316561
 AL021807  AL021917  AL031777  AL049822  AL353759
 AL591493  AY128653  AY128654  AY128655  AY128656
 AY128657  AY128658  AY128659  AY128661  AY128662
 AY128663  AY128664  AY128665  AY648850  B2R4R0
 BAA19208  BAG34857  BAG34965  BAG35087  BAG38150
 BAG70273  BC017361  BC054014  BC066248  BC066249
 BC066250  BC067495  BC067496  BC067497  BC069288
 BC069392  BC069467  BC069654  BC093763  BC093765
 BC093969  BC111093  BC111434  BC112193  BC120939
 BC128104  BC128105  BC130558  BC130560  BC143045
 BC148271  CAA16946  CAA24918  CAA43011  CAA43012
 CAA43013  CAA43014  CAA43016  CAA43017  CAA47464
 CAA58538  CAB011503  CAB021887  CAB02549  CAB037279
 CAC03414  CAC03418  CAC03426  CAC03427  CAC04128
 CAC69642  CAD24074  CAG46966  CAG46969  CAG46977
 CAG46984  CAG46986  CAI12560  CAI12567  CCDS30847
 CCDS30851  CCDS4571  CCDS4572  CCDS4583  CCDS4589
 CCDS4593  CCDS4598  CCDS4604  CCDS4620  CCDS4630
 CCDS4631  CCDS4637  CCDS8665  CH471081  CH471087
 CH471094  CR542169  CR542172  CR542180  CR542187
 CR542189  EAW55509  EAW55510  EAW55538  EAW55549
 EAW55555  EAW55556  EAW96325  EAX03086  EAX03111
 EAX03112  EAX03121  ENSG00000158406  ENSG00000197061  ENSG00000197238
 ENSG00000197837  ENSG00000270276  ENSG00000270882  ENSG00000273542  ENSG00000274618
 ENSG00000275126  ENSG00000276180  ENSG00000276966  ENSG00000277157  ENSG00000278637
 ENSG00000278705  ENSP00000244537  ENSP00000347168  ENSP00000350767  ENSP00000366956
 ENSP00000366974  ENSP00000367034  ENSP00000443017  ENSP00000462355  ENSP00000462667
 ENSP00000478519  ENSP00000478786  ENSP00000479106  ENSP00000479461  ENSP00000479794
 ENSP00000480960  ENSP00000481343  ENSP00000481486  ENSP00000481507  ENSP00000482412
 ENSP00000484789  ENSP00000489236  ENSP00000489319  ENSP00000489567  ENST00000244537
 ENST00000355057  ENST00000358064  ENST00000377727  ENST00000377745  ENST00000377803
 ENST00000539745  ENST00000578186  ENST00000579512  ENST00000611927  ENST00000612061
 ENST00000613412  ENST00000614247  ENST00000614272  ENST00000615164  ENST00000615353
 ENST00000617569  ENST00000618193  ENST00000618305  ENST00000621520  ENST00000634560
 ENST00000634956  ENST00000635491  EntrezGene:121504  EntrezGene:554313  EntrezGene:8294
 EntrezGene:8359  EntrezGene:8360  EntrezGene:8361  EntrezGene:8362  EntrezGene:8363
 EntrezGene:8364  EntrezGene:8365  EntrezGene:8366  EntrezGene:8367  EntrezGene:8368
 EntrezGene:8370  g11415029_3p_x_at  g4504322_3p_at  g5579462_3p_at  g5579463_3p_at
 g5579464_3p_at  g5579465_3p_at  g5579466_3p_a_at  g5579467_3p_at  GE499003
 GE501244  GE502647  GE506852  GE508495  GE561628
 GE572531  GE57844  GE58304  GE59861  GE79334
 GE81299  GE81300  GE86856  GE87998  GE903856
 GO:0000183  GO:0000228  GO:0000784  GO:0000786  GO:0000788
 GO:0002376  GO:0003674  GO:0003677  GO:0003723  GO:0005515
 GO:0005575  GO:0005576  GO:0005622  GO:0005623  GO:0005634
 GO:0005654  GO:0005694  GO:0006259  GO:0006303  GO:0006334
 GO:0006335  GO:0006336  GO:0006352  GO:0006412  GO:0006461
 GO:0006950  GO:0008150  GO:0009058  GO:0016020  GO:0016233
 GO:0019904  GO:0022607  GO:0030154  GO:0031012  GO:0032200
 GO:0034080  GO:0034641  GO:0042393  GO:0042592  GO:0043226
 GO:0043234  GO:0044267  GO:0045653  GO:0045814  GO:0045815
 GO:0046982  GO:0048856  GO:0051276  GO:0051290  GO:0060964
 GO:0065003  GO:0070062  GO:1904837  HGNC:20510  HGNC:29607
 HGNC:4781  HGNC:4782  HGNC:4783  HGNC:4784  HGNC:4785
 HGNC:4787  HGNC:4788  HGNC:4789  HGNC:4790  HGNC:4791
 HGNC:4793  HGNC:4794  HIST1H4A  HIST1H4A-201  HIST1H4B
 HIST1H4B-201  HIST1H4C  HIST1H4C-201  HIST1H4D  HIST1H4D-201
 HIST1H4E  HIST1H4E-201  HIST1H4F  HIST1H4F-201  HIST1H4H
 HIST1H4H-201  HIST1H4H-202  HIST1H4H-203  HIST1H4H-204  HIST1H4I
 HIST1H4I-201  HIST1H4J  HIST1H4J-201  HIST1H4K  HIST1H4K-201
 HIST1H4L  HIST1H4L-201  HIST2H4A  HIST2H4A-201  HIST2H4A-202
 HIST2H4A-203  HIST2H4A-204  HIST2H4B  HIST2H4B-201  HIST2H4B-202
 HIST2H4B-203  HIST4H4  HIST4H4-201  HIST4H4-204  HPA042201
 Hs.131957.0.S1_3p_at  Hs.132854.0.S1_3p_at  Hs.143080.0.S1_3p_at  Hs.737396  Hs.93758.1.S1_3p_at
 Hs.93758.1.S1_3p_x_at  ILMN_1662359  ILMN_1670033  ILMN_1676580  ILMN_1681542
 ILMN_1695199  ILMN_1698511  ILMN_1708811  ILMN_1713436  ILMN_1723111
 ILMN_1742688  ILMN_1751120  ILMN_1777454  ILMN_1782329  ILMN_1797905
 ILMN_2053992  ILMN_2075334  ILMN_2115340  ILMN_2119320  ILMN_2165369
 ILMN_2207865  ILMN_2224990  ILMN_3238233  IPR001951  IPR004823
 IPR009072  IPR019809  M16707  M16707_rna1_at  M16707_rna1_s_at
 M60749  M60749_at  MIM:142750  MIM:602822  MIM:602823
 MIM:602824  MIM:602825  MIM:602826  MIM:602827  MIM:602828
 MIM:602829  MIM:602830  MIM:602831  MIM:602833  MIM:615069
 NM_001034077  NM_003495  NM_003538  NM_003539  NM_003540
 NM_003541  NM_003542  NM_003543  NM_003544  NM_003545
 NM_003546  NM_003548  NM_021968  NM_175054  NP_001029249
 NP_003486  NP_003529  NP_003530  NP_003531  NP_003532
 NP_003533  NP_003534  NP_003535  NP_003536  NP_003537
 NP_003539  NP_068803  NP_778224  PF15511  PH_hs_0007863
 PH_hs_0012922  PH_hs_0013176  PH_hs_0013177  PH_hs_0017043  PH_hs_0027130
 PH_hs_0028888  PH_hs_0029036  PH_hs_0029514  PH_hs_0031203  PH_hs_0031792
 PH_hs_0032299  PH_hs_0032446  PH_hs_0033270  PH_hs_0034759  PH_hs_0034804
 PR00623  SM00417  SM00803  TC01001173.hg  TC01003192.hg
 TC06000163.hg  TC06000166.hg  TC06000172.hg  TC06000175.hg  TC06000224.hg
 TC06000266.hg  TC06001341.hg  TC06001348.hg  TC06001355.hg  TC06001424.hg
 TC06001427.hg  TC06001428.hg  TC06002644.hg  TC12001272.hg  uc001ess.4
 uc001esu.2  uc001etb.4  uc001rce.4  uc001rcf.5  uc003nfq.4
 uc003nfr.4  uc003ngi.4  uc003ngu.4  uc003ngy.5  uc003nhe.2
 uc003nhm.3  uc003niy.2  uc003njp.4  uc003njr.4  uc003njz.4
 uc031uxt.2  uc057kln.1  uc057klo.1  uc057klu.1  uc284pyf.1
 uc284pyg.1  uc284pyh.1  UPI000000003C  X00038  X00038_at
 X60481  X60482  X60483  X60483_at  X60484
 X60486  X60486_at  X60487  X60487_at  X67081
 X67081_at  X83548  Z80787  Z80787_at  Z98744
Participant Of
Other forms of this molecule
Inferred To
Cross References
UCSC human
GeneCards
ZINC target
PRO
Orphanet
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.766 Q9Y294 ASF1A_HUMAN 14
0.743 O75164 KDM4A_HUMAN 7
0.743 Q12888 TP53B_HUMAN 8
0.725 EBI-10097414 FOXP3_HUMAN_GENE 4
0.71 Q9NQR1 KMT5A_HUMAN 5
0.697 P49450 CENPA_HUMAN 4
0.688 Q13547 HDAC1_HUMAN 3
0.675 Q12830-4 BPTF 16
0.667 Q9Y468 LMBL1_HUMAN 4
0.662 Q15672 TWST1_HUMAN 5
0.659 P68431 H31_HUMAN 3
0.646 O60885-1 BRD4 7
0.618 Q9BVI0 PHF20_HUMAN 3
0.564 Q9UER7 DAXX_HUMAN 3
0.564 P63104 1433Z_HUMAN 3
0.564 Q8NCD3 HJURP_HUMAN 3
0.558 A8MW92 P20L1_HUMAN 2
0.558 EBI-9077146 7SK_HUMAN 2
0.558 P25440 BRD2_HUMAN 5
0.558 Q9VK33 SMBT_DROME 10
0.558 P55201 BRPF1_HUMAN 8
0.556 P35609 ACTN2_HUMAN 3
0.556 Q8IUQ4 SIAH1_HUMAN 3
0.544 O60264 SMCA5_HUMAN 2
0.527 P16104 H2AX_HUMAN 2
0.525 Q9NQ92 COPRS_HUMAN 3
0.499 Q09028 RBBP4_HUMAN 2
0.499 P49736 MCM2_HUMAN 3
0.499 Q16576 RBBP7_HUMAN 4
0.499 P25205 MCM3_HUMAN 2
0.499 O14929 HAT1_HUMAN 4
0.499 P33992 MCM5_HUMAN 2
0.488 Q05329 DCE2_HUMAN 2
0.488 Q96DZ9-2 CMTM5 2
0.462 Q9UHJ3 SMBT1_HUMAN 2