Reactome | Requirement by 'ECSIT [cytosol]'

Requirement by 'ECSIT [cytosol]'

Stable Identifier

R-HSA-181968

Type

Requirement

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TRAF6 binds MEKK1 (Homo sapiens)
        
        ECSIT [cytosol]

Regulation participants

Regulation type

Requirement

Regulated entity

TRAF6 binds MEKK1

Regulator

ECSIT [cytosol]

Cite Us!