Degradation of MHC I Complex

Stable Identifier
R-HSA-182263
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
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General
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Once the complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 arrives at the endosome, the MHC I complex is targeted for degradation.

Literature References
PubMed ID Title Journal Year
15569716 HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

Roeth, JF, Williams, M, Kasper, MR, Filzen, TM, Collins, KL

J Cell Biol 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created