Reactome | CDKN1B [nucleoplasm]

CDKN1B [nucleoplasm]

Stable Identifier

R-HSA-182563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p27

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P46527 CDKN1B

Gene Names

CDKN1B, KIP1

Chain

chain:1-198

Reference Genes

BioGPS Gene:1027 CDKN1B

COSMIC (genes):CDKN1B CDKN1B

CTD Gene:1027 CDKN1B

dbSNP Gene:1027 CDKN1B

ENSEMBL:ENSG00000111276 CDKN1B

HGNC:1785 CDKN1B

KEGG Gene (Homo sapiens):1027 CDKN1B

Monarch:1027 CDKN1B

NCBI Gene:1027 CDKN1B

OMIM:600778 CDKN1B

Reference Transcript

RefSeq:NM_004064.4 CDKN1B

Other Identifiers

0002100280

1027

11717091_s_at

11748603_a_at

16748477

1H27

1JSU

2034_s_at

209112_at

21888

2AST

33847_s_at

33848_r_at

3405445

3405446

3405449

3405455

3405456

3691

52535_s_at

59086

5UQ3

6ATH

7954029

A_14_P102019

A_23_P204696

A_24_P81841

AAA20240

AAD14244

AAH01971

AAL78041

AAV38360

AAV38361

AB451291

AB451423

AF480891

AK312461

BAG35368

BAG70105

BAG70237

BC001971

BT019553

BT019554

CAB003691

CAB021888

CAG33680

CCDS8653

CDKN1B

CDKN1B-201

CH471094

CR457399

E7ES52

EAW96275

ENSG00000111276

ENSP00000228872

ENST00000228872

ENST00000228872.8

EntrezGene:1027

EntrezGene:CDKN1B

g12805034_3p_at

GE81344

GO:0000003

GO:0000079

GO:0000082

GO:0000278

GO:0001666

GO:0001890

GO:0003674

GO:0004860

GO:0004861

GO:0005072

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006464

GO:0006810

GO:0006813

GO:0006950

GO:0006977

GO:0007010

GO:0007049

GO:0007050

GO:0007096

GO:0007165

GO:0007219

GO:0007507

GO:0007605

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009056

GO:0009058

GO:0009749

GO:0010942

GO:0014070

GO:0016301

GO:0016310

GO:0019899

GO:0019901

GO:0019903

GO:0022607

GO:0030154

GO:0030234

GO:0030308

GO:0030332

GO:0030544

GO:0031116

GO:0031410

GO:0031464

GO:0032355

GO:0032991

GO:0033673

GO:0034641

GO:0040007

GO:0042127

GO:0042326

GO:0042493

GO:0043066

GO:0043200

GO:0043226

GO:0043231

GO:0043434

GO:0044877

GO:0045732

GO:0045736

GO:0045737

GO:0045786

GO:0045787

GO:0045892

GO:0045930

GO:0046686

GO:0048102

GO:0048839

GO:0048856

GO:0050680

GO:0050877

GO:0051087

GO:0051271

GO:0060770

GO:0065003

GO:0071236

GO:0071285

GO:0071407

GO:0071850

GO:0140014

GO:1902746

GO:1904030

GO:1904706

GO:1905179

H7C2T1

HGNC:1785

HPA059086

ILMN_1722811

ILMN_2196347

IPR003175

IPR029843

MIM:600778

MIM:610755

NM_004064

NP_004055

PF02234

PH_hs_0012886

Q6I9V6

S76986

S76988

TC12000178.hg

TC12002253.hg

U10906

UPI0000035C92

Participant Of

input

CDKN1B is phosphorylated in response to estrogen

output

Translocation of p27 to the nucleoplasm

hasMember

Other forms of this molecule

CDKN1B [cytosol]

p-T157-CDKN1B [cytosol]

p-Y88-CDKN1B [nucleoplasm]

p-Y88-CDKN1B [cytosol]

p-T187-CDKN1B [nucleoplasm]

p-S10 CDKN1B [nucleoplasm]

p-S10 CDKN1B [cytosol]

Inferred To

CDKN1B [nucleoplasm] (Bos taurus)

CDKN1B [nucleoplasm] (Caenorhabditis elegans)

CDKN1B [nucleoplasm] (Danio rerio)

CDKN1B [nucleoplasm] (Gallus gallus)

CDKN1B [nucleoplasm] (Mus musculus)

CDKN1B [nucleoplasm] (Rattus norvegicus)

CDKN1B [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004055.1

OpenTargets

ENSG00000111276

GeneCards

P46527

PRO

P46527

Orphanet

18426

PDB

5UQ3, 6ATH, 1H27, 2AST, 1JSU

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.97	25
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.963	17
UniProt:P11802 CDK4	3	CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [cytosol] (R-HSA-68330)	0.904	7
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.875	8
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) Unfolded CCNE1 [cytosol] (R-HSA-6813836) CCNE1 [cytosol] (R-HSA-157443)	0.822	8
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.806	6
UniProt:P30279 CCND2	2	CCND2 [nucleoplasm] (R-HSA-113827) CCND2 [cytosol] (R-HSA-68340)	0.766	6
UniProt:P24385 CCND1	4	p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832)	0.758	4
UniProt:Q13309 SKP2	2	SKP2 [nucleoplasm] (R-HSA-975554) SKP2 [cytosol] (R-HSA-975495)	0.75	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.743	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.724	5
UniProt:O15131 KPNA5	2	KPNA5 [cytosol] (R-HSA-1176062) KPNA5 [nucleoplasm] (R-HSA-1176068)	0.718	6
UniProt:O96020 CCNE2	3	CCNE2 [cytosol] (R-HSA-157452) Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [nucleoplasm] (R-HSA-68367)	0.646	3
UniProt:P78396 CCNA1	3	CCNA1 [cytosol] (R-HSA-157446) PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [nucleoplasm] (R-HSA-68891)	0.646	5
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.646	3
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14-CDK1 [nucleoplasm] (R-HSA-170045)	0.643	3
UniProt:Q62120 Jak2	11	phospho-p-JAK2 [cytosol] (R-MMU-210621) p-Jak2 [cytosol] (R-MMU-8950633) phospho-p-Y1007,Y1008-JAK2 [cytosol] (R-MMU-9005327) phospho-p-Y813-JAK2 [cytosol] (R-MMU-997248) JAK2 [endosome lumen] (R-MMU-2002372) p-Y1007-Jak2 [cytosol] (R-MMU-997296) p-12Y-Jak2 [cytosol] (R-MMU-2586515) phospho-p-12Y-JAK2 [cytosol] (R-MMU-2586516) Jak2 [cytosol] (R-MMU-205743) JAK2 [cytosol] (R-MMU-210620) phospho-p-Y1007-JAK2 [cytosol] (R-MMU-873799)	0.626	7
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551)	0.609	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.602	3
UniProt:P16949 STMN1	1	STMN1 [cytosol] (R-HSA-9612290)	0.589	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.576	4
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.564	2
UniProt:P14635 CCNB1	4	CCNB1 [cytosol] (R-HSA-157451) CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049)	0.564	2
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.547	2
UniProt:Q15418 RPS6KA1	7	p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.544	2
UniProt:P07948 LYN	5	p-Y396-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.544	2
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [cell junction] (R-HSA-2134503) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [plasma membrane] (R-HSA-194510)	0.544	3
UniProt:Q00526 CDK3			0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.524	2
UniProt:Q9UQR0-1 SCML2			0.499	2
UniProt:P70168 Kpnb1	5	KPNB1 [extracellular region] (R-MMU-6806306) KPNB1 [specific granule lumen] (R-MMU-6799646) KPNB1 [ficolin-1-rich granule lumen] (R-MMU-6800978) Importin subunit beta-1 [cytosol] (R-MMU-2065541) KPNB1 [nucleoplasm] (R-MMU-180714)	0.499	4
UniProt:P11440 Cdk1	10	Cdk1 [nucleoplasm] (R-MMU-1362302) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424) CDK1 [cytosol] (R-MMU-170075) phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078)	0.499	2
UniProt:Q5MJ70 SPDYA			0.488	2
UniProt:Q5JR59-3 MTUS2			0.488	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.463	2