Reactome | CDKN1B [nucleoplasm]

CDKN1B [nucleoplasm]

Stable Identifier

R-HSA-182563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p27

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46527 CDKN1B

Gene Names

CDKN1B, KIP1

Chain

chain:1-198

Reference Genes

BioGPS Gene:1027 CDKN1B

COSMIC (genes):CDKN1B CDKN1B

CTD Gene:1027 CDKN1B

dbSNP Gene:1027 CDKN1B

ENSEMBL:ENSG00000111276 CDKN1B

HGNC:1785 CDKN1B

KEGG Gene (Homo sapiens):1027 CDKN1B

Monarch:1027 CDKN1B

NCBI Gene:1027 CDKN1B

OMIM:600778 CDKN1B

Reference Transcript

RefSeq:NM_004064.4 CDKN1B

Other Identifiers

0002100280

1027

11717091_s_at

11748603_a_at

16748477

2034_s_at

209112_at

33847_s_at

33848_r_at

3405445

3405446

3405449

3405455

3405456

52535_s_at

7954029

A_14_P102019

A_23_P204696

A_24_P81841

GE81344

GO:0000003

GO:0000079

GO:0000082

GO:0000278

GO:0001666

GO:0001890

GO:0003674

GO:0004860

GO:0004861

GO:0005072

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006464

GO:0006810

GO:0006813

GO:0006950

GO:0006977

GO:0007010

GO:0007049

GO:0007050

GO:0007096

GO:0007165

GO:0007219

GO:0007507

GO:0007605

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009056

GO:0009058

GO:0009749

GO:0010942

GO:0014070

GO:0016301

GO:0016310

GO:0019899

GO:0019901

GO:0019903

GO:0022607

GO:0030154

GO:0030234

GO:0030308

GO:0030332

GO:0030544

GO:0031116

GO:0031410

GO:0031464

GO:0032355

GO:0032991

GO:0033673

GO:0034641

GO:0040007

GO:0042127

GO:0042326

GO:0042493

GO:0043066

GO:0043200

GO:0043226

GO:0043231

GO:0043434

GO:0044877

GO:0045732

GO:0045736

GO:0045737

GO:0045786

GO:0045787

GO:0045892

GO:0045930

GO:0046686

GO:0048102

GO:0048839

GO:0048856

GO:0050680

GO:0050877

GO:0051087

GO:0051271

GO:0060770

GO:0065003

GO:0071236

GO:0071285

GO:0071407

GO:0071850

GO:0140014

GO:1902746

GO:1904030

GO:1904706

GO:1905179

ILMN_1722811

ILMN_2196347

PH_hs_0012886

TC12000178.hg

TC12002253.hg

g12805034_3p_at

Participant Of

input

CDKN1B is phosphorylated in response to estrogen

output

Translocation of p27 to the nucleoplasm

hasMember

Other forms of this molecule

p-Y88-CDKN1B [nucleoplasm]

p-Y88-CDKN1B [cytosol]

CDKN1B [cytosol]

p-T187-CDKN1B [nucleoplasm]

p-T157-CDKN1B [cytosol]

p-S10 CDKN1B [nucleoplasm]

p-S10 CDKN1B [cytosol]

Inferred To

dap [nucleoplasm] (Drosophila melanogaster)

cdkn1bb [nucleoplasm] (Danio rerio)

cki-2 [nucleoplasm] (Caenorhabditis elegans)

CDKN1B [nucleoplasm] (Bos taurus)

CDKN1B [nucleoplasm] (Gallus gallus)

p27Kip1 [nucleoplasm] (Sus scrofa)

Cdkn1b [nucleoplasm] (Mus musculus)

Cdkn1b [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_004055.1

OpenTargets

ENSG00000111276

HPA

ENSG00000111276-CDKN1B

GeneCards

P46527

Ensembl

ENST00000228872, ENSG00000111276, ENSP00000228872

PRO

P46527

Orphanet

18426

PDB

6P8F, 1JSU, 5UQ3, 6P8G, 6P8E, 1H27, 2AST, 6ATH

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.97	25
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.963	17
UniProt:P11802 CDK4	3	CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [cytosol] (R-HSA-68330)	0.904	7
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.875	8
UniProt:P24864 CCNE1	3	CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836) CCNE1 [nucleoplasm] (R-HSA-68363)	0.822	8
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.806	6
UniProt:P30279 CCND2	2	CCND2 [nucleoplasm] (R-HSA-113827) CCND2 [cytosol] (R-HSA-68340)	0.766	6
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.758	4
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.75	4
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.743	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.724	5
UniProt:O15131 KPNA5	2	KPNA5 [cytosol] (R-HSA-1176062) KPNA5 [nucleoplasm] (R-HSA-1176068)	0.718	6
UniProt:O96020 CCNE2	3	CCNE2 [cytosol] (R-HSA-157452) Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [nucleoplasm] (R-HSA-68367)	0.646	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.646	3
UniProt:P78396 CCNA1	3	CCNA1 [cytosol] (R-HSA-157446) PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [nucleoplasm] (R-HSA-68891)	0.646	5
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.643	3
UniProt:Q62120 Jak2	11	Jak2 [cytosol] (R-MMU-210620) phospho-Jak2 [cytosol] (R-MMU-873799) Jak2 [cytosol] (R-MMU-205743) phospho-Jak2 [cytosol] (R-MMU-2586516) p-12Y-Jak2 [cytosol] (R-MMU-2586515) p-Y1007-Jak2 [cytosol] (R-MMU-997296) Jak2 [endosome lumen] (R-MMU-2002372) phospho-Jak2 [cytosol] (R-MMU-997248) phospho-Jak2 [cytosol] (R-MMU-9005327) phospho-Jak2 [cytosol] (R-MMU-210621) p-Jak2 [cytosol] (R-MMU-8950633)	0.626	7
UniProt:Q13616 CUL1	3	CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [cytosol] (R-HSA-174230)	0.609	2
UniProt:Q92905 COPS5	2	COPS5 [cytosol] (R-HSA-416963) COPS5 [nucleoplasm] (R-HSA-5697019)	0.602	3
UniProt:P16949 STMN1	1	STMN1 [cytosol] (R-HSA-9612290)	0.589	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.576	4
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.564	2
UniProt:P14635 CCNB1	4	CCNB1 [cytosol] (R-HSA-157451) CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049)	0.564	2
UniProt:Q5MJ70 SPDYA			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.547	2
UniProt:Q15418 RPS6KA1	7	p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.544	2
UniProt:P61586 RHOA	6	RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.544	3
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y396-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.544	2
UniProt:Q00526 CDK3			0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.524	2
UniProt:P70168 Kpnb1	5	Kpnb1 [extracellular region] (R-MMU-6806306) Kpnb1 [specific granule lumen] (R-MMU-6799646) Kpnb1 [ficolin-1-rich granule lumen] (R-MMU-6800978) Kpnb1 [nucleoplasm] (R-MMU-180714) Importin subunit beta-1 [cytosol] (R-MMU-2065541)	0.499	4
UniProt:P11440 Cdk1	10	phospho-Cdk1 [nucleoplasm] (R-MMU-170074) phospho-Cdk1 [nucleoplasm] (R-MMU-170078) phospho-Cdk1 [nucleoplasm] (R-MMU-170045) phospho-Cdk1 [cytosol] (R-MMU-170064) phospho-Cdk1 [cytosol] (R-MMU-170071) phospho-Cdk1 [cytosol] (R-MMU-157415) phospho-Cdk1 [nucleoplasm] (R-MMU-170066) Cdk1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) Cdk1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2
UniProt:Q9UQR0-1 SCML2			0.499	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.463	2

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