Reactome | CDKN2C [cytosol]

CDKN2C [cytosol]

Stable Identifier

R-HSA-182572

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P42773 CDKN2C

Gene Names

CDKN2C, CDKN6

Chain

chain:1-168

Reference Genes

BioGPS Gene:1031 CDKN2C

COSMIC (genes):CDKN2C CDKN2C

CTD Gene:1031 CDKN2C

dbSNP Gene:1031 CDKN2C

ENSEMBL:ENSG00000123080 CDKN2C

HGNC:1789 CDKN2C

KEGG:hsa:1031 CDKN2C

Monarch:1031 CDKN2C

NCBI Gene:1031 CDKN2C

OMIM:603369 CDKN2C

UCSC:P42773 CDKN2C

Reference Transcript

Other Identifiers

1031

11743051_s_at

11758661_s_at

16664569

204159_PM_at

204159_at

211792_PM_s_at

211792_s_at

2335923

2335924

2335925

2335926

2335927

2335928

2335929

2335931

2335936

2335937

2335938

36053_at

7901363

A_14_P109987

A_23_P85460

A_33_P3292540

GE54358

GO:0000079

GO:0004861

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0008283

GO:0008285

GO:0019901

GO:0030154

GO:0030308

GO:0042326

GO:0043226

GO:0048709

GO:0072089

GO:0098772

GO:2000045

GO:2000647

HMNXSV003041257

ILMN_1652171

ILMN_1656415

ILMN_1710701

ILMN_1866628

ILMN_2359332

PH_hs_0000490

TC01000619.hg

g4502750_3p_at

g639713_3p_a_at

Participates

as a member of

INK4 [cytosol] (Homo sapiens)

Inferred To

cdkn2c [cytosol] (Xenopus tropicalis)

CDKN2C [cytosol] (Bos taurus)

CDKN2C [cytosol] (Canis familiaris)

CDKN2C [cytosol] (Gallus gallus)

CDKN2C [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_523240.1, NP_001253.1

ENSEMBL

ENSP00000262662, ENSP00000360826, ENST00000262662, ENST00000396148, ENSP00000379452, ENST00000371761

OpenTargets

ENSG00000123080

HPA

ENSG00000123080-CDKN2C

PRO

P42773

Pharos - Targets

P42773

Orphanet

CDKN2C

PDB

1MX6, 1MX4, 1IHB, 1G3N, 1MX2, 1BU9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.972	28
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.971	29
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	5
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.527	3
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.527	4
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2

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