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CDKN1A [nucleoplasm]
Stable Identifier
R-HSA-182585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p21
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional activation of p53 responsive genes (Homo sapiens)
Transcriptional activation of cell cycle inhibitor p21 (Homo sapiens)
PCBP4 modulates CDKN1A translation (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Translocation of p21 to the nucleus (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Homo sapiens)
Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Translocation of p21 to the nucleus (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA binds CDKN1A (p21) (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
CEBPA:CDKN1A [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
PCBP4 modulates CDKN1A translation (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B [nucleoplasm] (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
PCBP4 modulates CDKN1A translation (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates CDKN1A transcription (Homo sapiens)
CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of cell cycle factors (Homo sapiens)
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)
CDKN1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38936 CDKN1A
Gene Names
CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Chain
initiator methionine:1, chain:2-164
Reference Genes
BioGPS Gene:1026 CDKN1A
COSMIC (genes):CDKN1A CDKN1A
CTD Gene:1026 CDKN1A
dbSNP Gene:1026 CDKN1A
ENSEMBL:ENSG00000124762 CDKN1A
HGNC:1784 CDKN1A
KEGG Gene (Homo sapiens):1026 CDKN1A
Monarch:1026 CDKN1A
NCBI Gene:1026 CDKN1A
OMIM:116899 CDKN1A
UCSC:P38936 CDKN1A
Reference Transcript
RefSeq:NM_001220778.1 CDKN1A
RefSeq:NM_001220777.1 CDKN1A
RefSeq:NM_001291549.1 CDKN1A
RefSeq:NM_078467.2 CDKN1A
RefSeq:NM_000389.4 CDKN1A
Other Identifiers
0001850504
0005270148
1026
11715387_at
11715388_s_at
17008007
202284_s_at
2031_s_at
2905173
2905175
2905176
2905177
2905178
2905183
2905184
2905189
2905193
2905194
2905195
8119088
A_23_P59210
A_24_P89457
GE58861
GO:0000079
GO:0000082
GO:0000086
GO:0000278
GO:0000307
GO:0002376
GO:0003674
GO:0004860
GO:0004861
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006259
GO:0006357
GO:0006367
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006950
GO:0006974
GO:0006977
GO:0006978
GO:0007049
GO:0007050
GO:0007095
GO:0007165
GO:0007265
GO:0007346
GO:0007507
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0009411
GO:0009636
GO:0010033
GO:0010165
GO:0010243
GO:0010629
GO:0010942
GO:0014070
GO:0015031
GO:0016301
GO:0016310
GO:0016604
GO:0019221
GO:0019899
GO:0019901
GO:0019912
GO:0021700
GO:0030154
GO:0030234
GO:0030308
GO:0030332
GO:0030890
GO:0031100
GO:0031625
GO:0031668
GO:0032091
GO:0032991
GO:0034198
GO:0034605
GO:0034641
GO:0040007
GO:0042060
GO:0042246
GO:0042326
GO:0042493
GO:0042771
GO:0043066
GO:0043068
GO:0043167
GO:0043226
GO:0044877
GO:0045736
GO:0045860
GO:0046685
GO:0046872
GO:0048146
GO:0048471
GO:0048856
GO:0050821
GO:0051384
GO:0051412
GO:0051726
GO:0055093
GO:0060574
GO:0070557
GO:0071479
GO:0071480
GO:0071493
GO:0071850
GO:0072331
GO:0090398
GO:0090399
GO:0090400
GO:0097193
GO:0140311
GO:1902806
GO:1904030
GO:1904031
GO:1904706
GO:1905179
GO:2000134
GO:2000278
GO:2000279
GO:2000379
ILMN_1784602
ILMN_1787212
PH_hs_0024155
U09579_at
g11386202_3p_a_at
Participant Of
output
CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3
CDKN1A gene expression is inhibited by RUNX2
CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C
CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4
FLT3 ITD- and STAT5-dependent CDKN1A gene expression
PCBP4 modulates CDKN1A translation
Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
Translocation of p21 to the nucleus
hasComponent
CEBPA:CDKN1A [nucleoplasm]
input
CEBPA binds CDKN1A (p21)
hasMember
CDKN1A,CDKN1B [nucleoplasm]
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm]
Other forms of this molecule
p-T145-CDKN1A [cytosol]
p-Y77-CDKN1A [cytosol]
CDKN1A [cytosol]
p-S130-CDKN1A [nucleoplasm]
Inferred To
Cdkn1a [nucleoplasm] (Mus musculus)
Cdkn1a [nucleoplasm] (Rattus norvegicus)
CDKN1A [nucleoplasm] (Bos taurus)
CDKN1A [nucleoplasm] (Canis familiaris)
CDKN1A [nucleoplasm] (Gallus gallus)
CDKN1A [nucleoplasm] (Sus scrofa)
cdkn1a [nucleoplasm] (Danio rerio)
notch3 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001207706.1
,
NP_001278478.1
,
NP_001207707.1
,
NP_000380.1
,
NP_510867.1
OpenTargets
ENSG00000124762
GeneCards
P38936
ZINC - Substances
CDN1A_HUMAN
HPA
ENSG00000124762-CDKN1A
ZINC target
P38936
Ensembl
ENST00000373711
,
ENST00000244741
,
ENST00000405375
,
ENSG00000124762
,
ENST00000448526
,
ENSP00000244741
,
ENSP00000384849
,
ENST00000615513
,
ENSP00000362815
,
ENSP00000409259
,
ENSP00000482768
PRO
P38936
ZINC - Predictions - Purchasable
CDN1A_HUMAN
Orphanet
20849
PDB
6CEJ
,
1AXC
,
6P8H
,
6CIV
,
4RJF
,
5E0U
,
6CIX
,
2ZVV
,
2ZVW
,
6CBI
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12004 PCNA
5
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
SUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.976
37
UniProt:P24941 CDK2
5
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.975
29
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.961
24
UniProt:P24385 CCND1
4
CCND1 [cytosol]
(R-HSA-68328)
CCND1 [nucleoplasm]
(R-HSA-113832)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.952
18
UniProt:P30279 CCND2
2
CCND2 [nucleoplasm]
(R-HSA-113827)
CCND2 [cytosol]
(R-HSA-68340)
0.946
17
UniProt:P11802 CDK4
3
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
CDK4 [cytosol]
(R-HSA-68330)
0.883
7
UniProt:P78396 CCNA1
3
CCNA1 [cytosol]
(R-HSA-157446)
PolyUb-CCNA1 [nucleoplasm]
(R-HSA-6783068)
CCNA1 [nucleoplasm]
(R-HSA-68891)
0.855
8
UniProt:O96020 CCNE2
3
CCNE2 [cytosol]
(R-HSA-157452)
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.851
6
UniProt:P24864 CCNE1
3
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
CCNE1 [nucleoplasm]
(R-HSA-68363)
0.818
9
UniProt:Q00526 CDK3
0.801
6
UniProt:P06493 CDK1
10
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
CDK1 [cytosol]
(R-HSA-170075)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
0.798
5
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [nucleoplasm]
(R-HSA-8863586)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
0.793
5
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.744
5
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:Q9BYV2 TRI54
0.718
6
UniProt:O94921 CDK14
0.706
8
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
0.688
3
UniProt:P14635 CCNB1
4
CCNB1 [cytosol]
(R-HSA-157451)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
0.688
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [cytosol]
(R-HSA-5654207)
SPRED1 [plasma membrane]
(R-HSA-5658225)
0.666
4
UniProt:Q8IYF3 TEX11
0.666
4
UniProt:P03129 VE7
0.656
6
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.654
3
UniProt:Q9BQ15 NABP2
1
NABP2 [nucleoplasm]
(R-HSA-6814916)
0.619
7
UniProt:Q99741 CDC6
4
p-CDC6 [cytosol]
(R-HSA-68583)
CDC6 [cytosol]
(R-HSA-113566)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
CDC6 [nucleoplasm]
(R-HSA-68542)
0.609
2
UniProt:O75419 CDC45
1
CDC45 [nucleoplasm]
(R-HSA-68563)
0.609
2
UniProt:Q00534 CDK6
3
CDK6 [nucleoplasm]
(R-HSA-141283)
CDK6 [cytosol]
(R-HSA-68336)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.59
2
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.589
3
UniProt:O75460-2 ERN1
0.556
3
UniProt:Q6ZSJ9 SHSA6
0.556
3
UniProt:P22607 FGFR3
40
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 795fs*139 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
p-6Y-FGFR3 S371C [plasma membrane]
(R-HSA-2011886)
p-6Y-FGFR3 G370C [plasma membrane]
(R-HSA-2011883)
p-6Y-FGFR3 Y373C [plasma membrane]
(R-HSA-2011889)
p-6Y-FGFR3 795fs*139 [plasma membrane]
(R-HSA-2038360)
p-6Y-FGFR3 R248C [plasma membrane]
(R-HSA-2011884)
pY-FGFR3 [plasma membrane]
(R-HSA-2038368)
p-6Y-FGFR3 K650Q [plasma membrane]
(R-HSA-2032962)
p-6Y-FGFR3 K650N [plasma membrane]
(R-HSA-2032961)
p-6Y-FGFR3 K650E [plasma membrane]
(R-HSA-2032952)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853147)
p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853155)
p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853145)
p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853129)
p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853151)
p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853128)
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
0.556
3
UniProt:P31321 PRKAR1B
2
PRKAR1B [ciliary base]
(R-HSA-5610409)
PRKAR1B [cytosol]
(R-HSA-57838)
0.556
3
UniProt:P41091 EIF2S3
1
EIF2S3 [cytosol]
(R-HSA-72514)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q9P2M1 LR2BP
0.556
3
UniProt:Q9BVV2 FND11
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:P51692 STAT5B
5
p-STAT5B [cytosol]
(R-HSA-8983127)
p-STAT5B [nucleoplasm]
(R-HSA-8982834)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
STAT5B [cytosol]
(R-HSA-380737)
0.556
3
UniProt:P49591 SARS1
1
SARS [cytosol]
(R-HSA-379691)
0.556
3
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:P06396 GSN
7
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q8NFF5 FLAD1
1
FLAD1 [cytosol]
(R-HSA-196980)
0.553
2
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.527
2
UniProt:Q9UQR0-1 SCML2
0.525
3
UniProt:Q9UHC7 MKRN1
2
MKRN1 [cytosol]
(R-HSA-976042)
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
0.524
5
UniProt:Q61187 Tsg101
2
Tsg101 [endosome membrane]
(R-MMU-2980549)
Tsg101 [endosome membrane]
(R-MMU-9631185)
0.508
3
UniProt:Q96FS4 SIPA1
1
SIPA1 [cytosol]
(R-HSA-392495)
0.508
2
UniProt:P27958-PRO_0000037566
0.499
3
UniProt:P35998 PSMC2
5
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
0.488
2
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