Reactome | CDKN1A [nucleoplasm]

CDKN1A [nucleoplasm]

Stable Identifier

R-HSA-182585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p21

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
      - Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
        
        Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
        
        CDKN1A [nucleoplasm] (Homo sapiens)
- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - FLT3 signaling in disease (Homo sapiens)
    - Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
      - STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
        
        FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
        
        CDKN1A [nucleoplasm] (Homo sapiens)
    - Signaling by FLT3 fusion proteins (Homo sapiens)
      - FLT3 ITD- and STAT5-dependent CDKN1A gene expression (Homo sapiens)
        
        CDKN1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38936 CDKN1A

Gene Names

CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Chain

initiator methionine:1, chain:2-164

Reference Genes

BioGPS Gene:1026 CDKN1A

COSMIC (genes):CDKN1A CDKN1A

CTD Gene:1026 CDKN1A

dbSNP Gene:1026 CDKN1A

ENSEMBL:ENSG00000124762 CDKN1A

HGNC:1784 CDKN1A

KEGG Gene (Homo sapiens):1026 CDKN1A

Monarch:1026 CDKN1A

NCBI Gene:1026 CDKN1A

OMIM:116899 CDKN1A

UCSC:P38936 CDKN1A

Reference Transcript

Other Identifiers

0001850504

0005270148

1026

11715387_at

11715388_s_at

17008007

202284_s_at

2031_s_at

2905173

2905175

2905176

2905177

2905178

2905183

2905184

2905189

2905193

2905194

2905195

8119088

A_23_P59210

A_24_P89457

GE58861

GO:0000079

GO:0000082

GO:0000086

GO:0000278

GO:0000307

GO:0002376

GO:0003674

GO:0004860

GO:0004861

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006259

GO:0006357

GO:0006367

GO:0006464

GO:0006606

GO:0006810

GO:0006913

GO:0006950

GO:0006974

GO:0006977

GO:0006978

GO:0007049

GO:0007050

GO:0007095

GO:0007165

GO:0007265

GO:0007346

GO:0007507

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0009411

GO:0009636

GO:0010033

GO:0010165

GO:0010243

GO:0010629

GO:0010942

GO:0014070

GO:0015031

GO:0016301

GO:0016310

GO:0016604

GO:0019221

GO:0019899

GO:0019901

GO:0019912

GO:0021700

GO:0030154

GO:0030234

GO:0030308

GO:0030332

GO:0030890

GO:0031100

GO:0031625

GO:0031668

GO:0032091

GO:0032991

GO:0034198

GO:0034605

GO:0034641

GO:0040007

GO:0042060

GO:0042246

GO:0042326

GO:0042493

GO:0042771

GO:0043066

GO:0043068

GO:0043167

GO:0043226

GO:0044877

GO:0045736

GO:0045860

GO:0046685

GO:0046872

GO:0048146

GO:0048471

GO:0048856

GO:0050821

GO:0051384

GO:0051412

GO:0051726

GO:0055093

GO:0060574

GO:0070557

GO:0071479

GO:0071480

GO:0071493

GO:0071850

GO:0072331

GO:0090398

GO:0090399

GO:0090400

GO:0097193

GO:0140311

GO:1902806

GO:1904030

GO:1904031

GO:1904706

GO:1905179

GO:2000134

GO:2000278

GO:2000279

GO:2000379

ILMN_1784602

ILMN_1787212

PH_hs_0024155

U09579_at

g11386202_3p_a_at

Participant Of

output

hasComponent

CEBPA:CDKN1A [nucleoplasm]

input

CEBPA binds CDKN1A (p21)

hasMember

Other forms of this molecule

p-T145-CDKN1A [cytosol]

p-Y77-CDKN1A [cytosol]

CDKN1A [cytosol]

p-S130-CDKN1A [nucleoplasm]

Inferred To

Cdkn1a [nucleoplasm] (Mus musculus)

Cdkn1a [nucleoplasm] (Rattus norvegicus)

CDKN1A [nucleoplasm] (Bos taurus)

CDKN1A [nucleoplasm] (Canis familiaris)

CDKN1A [nucleoplasm] (Gallus gallus)

CDKN1A [nucleoplasm] (Sus scrofa)

cdkn1a [nucleoplasm] (Danio rerio)

notch3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001207706.1, NP_001278478.1, NP_001207707.1, NP_000380.1, NP_510867.1

OpenTargets

ENSG00000124762

GeneCards

P38936

ZINC - Substances

CDN1A_HUMAN

HPA

ENSG00000124762-CDKN1A

ZINC target

P38936

Ensembl

ENST00000373711, ENST00000244741, ENST00000405375, ENSG00000124762, ENST00000448526, ENSP00000244741, ENSP00000384849, ENST00000615513, ENSP00000362815, ENSP00000409259, ENSP00000482768

PRO

P38936

ZINC - Predictions - Purchasable

CDN1A_HUMAN

Orphanet

20849

PDB

6CEJ, 1AXC, 6P8H, 6CIV, 4RJF, 5E0U, 6CIX, 2ZVV, 2ZVW, 6CBI

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12004 PCNA	5	K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.976	37
UniProt:P24941 CDK2	5	p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.975	29
UniProt:P30281 CCND3	2	CCND3 [cytosol] (R-HSA-68333) CCND3 [nucleoplasm] (R-HSA-113835)	0.961	24
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.952	18
UniProt:P30279 CCND2	2	CCND2 [nucleoplasm] (R-HSA-113827) CCND2 [cytosol] (R-HSA-68340)	0.946	17
UniProt:P11802 CDK4	3	CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [cytosol] (R-HSA-68330)	0.883	7
UniProt:P78396 CCNA1	3	CCNA1 [cytosol] (R-HSA-157446) PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [nucleoplasm] (R-HSA-68891)	0.855	8
UniProt:O96020 CCNE2	3	CCNE2 [cytosol] (R-HSA-157452) Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [nucleoplasm] (R-HSA-68367)	0.851	6
UniProt:P24864 CCNE1	3	CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836) CCNE1 [nucleoplasm] (R-HSA-68363)	0.818	9
UniProt:Q00526 CDK3			0.801	6
UniProt:P06493 CDK1	10	CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [cytosol] (R-HSA-170075) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)	0.798	5
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [nucleoplasm] (R-HSA-8863586) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249)	0.793	5
UniProt:P20248 CCNA2	3	CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [nucleoplasm] (R-HSA-68905)	0.744	5
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q9BYV2 TRI54			0.718	6
UniProt:O94921 CDK14			0.706	8
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.688	3
UniProt:P14635 CCNB1	4	CCNB1 [cytosol] (R-HSA-157451) CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049)	0.688	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.666	4
UniProt:Q8IYF3 TEX11			0.666	4
UniProt:P03129 VE7			0.656	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.654	3
UniProt:Q9BQ15 NABP2	1	NABP2 [nucleoplasm] (R-HSA-6814916)	0.619	7
UniProt:Q99741 CDC6	4	p-CDC6 [cytosol] (R-HSA-68583) CDC6 [cytosol] (R-HSA-113566) p-CDC6 [nucleoplasm] (R-HSA-5661317) CDC6 [nucleoplasm] (R-HSA-68542)	0.609	2
UniProt:O75419 CDC45	1	CDC45 [nucleoplasm] (R-HSA-68563)	0.609	2
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.59	2
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.589	3
UniProt:O75460-2 ERN1			0.556	3
UniProt:Q6ZSJ9 SHSA6			0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [ciliary base] (R-HSA-5610409) PRKAR1B [cytosol] (R-HSA-57838)	0.556	3
UniProt:P41091 EIF2S3	1	EIF2S3 [cytosol] (R-HSA-72514)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q9P2M1 LR2BP			0.556	3
UniProt:Q9BVV2 FND11			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:P51692 STAT5B	5	p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016) p-Y699-STAT5B [cytosol] (R-HSA-507939) STAT5B [cytosol] (R-HSA-380737)	0.556	3
UniProt:P49591 SARS1	1	SARS [cytosol] (R-HSA-379691)	0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.553	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	2
UniProt:Q9UQR0-1 SCML2			0.525	3
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.524	5
UniProt:Q61187 Tsg101	2	Tsg101 [endosome membrane] (R-MMU-2980549) Tsg101 [endosome membrane] (R-MMU-9631185)	0.508	3
UniProt:Q96FS4 SIPA1	1	SIPA1 [cytosol] (R-HSA-392495)	0.508	2
UniProt:P27958-PRO_0000037566			0.499	3
UniProt:P35998 PSMC2	5	PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.488	2

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