Reactome | SH3GL2 [cytosol]

SH3GL2 [cytosol]

Stable Identifier

R-HSA-182958

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Endophilin

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Listeria monocytogenes entry into host cells (Homo sapiens)
    - InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
      - CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)
        
        InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        InlB:MonoUb-K,p-4Y-MET:GRB2-1:p-Y-CBL:CIN85:endophilin:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        InlB:MonoUb-K,p-4Y-MET dimer:GRB2-1:p-Y-CBL:CIN85:endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - EGFR downregulation (Homo sapiens)
      - Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - CBL-mediated ubiquitination of CIN85 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        Ub-CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - EGFR non-clathrin mediated endocytosis (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - EGFR phosphorylates EPS15 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PTPN3 dephosphorylates EPS15 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - Sprouty sequesters CBL away from active EGFR (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        CIN85:endophilin [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
        
        SH3GLs [cytosol] (Homo sapiens)
        
        SH3GL2 dimer [cytosol] (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - trans-Golgi Network Coat Assembly (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - trans-Golgi Network Vesicle Scission (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
    - Lysosome Vesicle Biogenesis (Homo sapiens)
      - trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Homo sapiens)
        
        SH3GL2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99962 SH3GL2

Gene Names

SH3GL2, CNSA2, SH3D2A

Chain

chain:1-352

Reference Genes

BioGPS Gene:6456 SH3GL2

COSMIC (genes):SH3GL2 SH3GL2

CTD Gene:6456 SH3GL2

dbSNP Gene:6456 SH3GL2

ENSEMBL:ENSG00000107295 SH3GL2

HGNC:10831 SH3GL2

KEGG Gene (Homo sapiens):6456 SH3GL2

Monarch:6456 SH3GL2

NCBI Gene:6456 SH3GL2

OMIM:604465 SH3GL2

UCSC:Q99962 SH3GL2

Reference Transcript

RefSeq:NM_003026.3 SH3GL2

Other Identifiers

0006660017

11730182_a_at

11730183_s_at

17083776

205751_PM_at

205751_at

3163827

3163828

3163829

3163830

3163831

3163860

3163861

3163863

3163866

3163868

3163869

3163870

3163871

3163872

3163873

3163874

3163875

40378_at

6456

8154476

A_14_P101372

A_23_P169351

GE54291

GO:0000139

GO:0000902

GO:0001933

GO:0003013

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0005886

GO:0006464

GO:0006810

GO:0006897

GO:0007165

GO:0007417

GO:0008150

GO:0008289

GO:0010629

GO:0016020

GO:0016191

GO:0016192

GO:0030054

GO:0030154

GO:0030669

GO:0031175

GO:0031410

GO:0040007

GO:0042592

GO:0042802

GO:0042995

GO:0043226

GO:0045202

GO:0048471

GO:0048856

GO:0097484

GO:0098793

GO:0098978

GO:1905604

GO:1990416

HMNXSV003007293

ILMN_1661491

TC09000085.hg

X99657_at

g4506930_3p_at

Participates

as an input of

as an output of

as a component of

SH3GL2 dimer [cytosol] (Homo sapiens)

Other forms of this molecule

SH3GL2 [plasma membrane]

SH3GL2 [clathrin-coated endocytic vesicle membrane]

SH3GL2 [Golgi membrane]

Inferred To

sh3gl2 [cytosol] (Xenopus tropicalis)

SH3GL2 [cytosol] (Bos taurus)

SH3GL2 [cytosol] (Canis familiaris)

SH3GL2 [cytosol] (Gallus gallus)

SH3GL2 [cytosol] (Schizosaccharomyces pombe)

SH3GL2 [cytosol] (Sus scrofa)

EndoA [cytosol] (Drosophila melanogaster)

Sh3gl2 [cytosol] (Mus musculus)

Sh3gl2 [cytosol] (Rattus norvegicus)

sh3gl2a [cytosol] (Danio rerio)

unc-57 [cytosol] (Caenorhabditis elegans)

PIN3 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_003017.1

OpenTargets

ENSG00000107295

HPA

ENSG00000107295-SH3GL2

GeneCards

Q99962

Ensembl

ENST00000380607, ENSP00000369981, ENSG00000107295

PRO

Q99962

Pharos - Targets

Q99962

PDB

1X03, 2D4C, 1X04, 2DBM

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.788	5
UniProt:Q99700 ATX2			0.779	9
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.744	4
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.722	4
UniProt:Q70E73 RAPH1			0.72	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.681	4
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.667	4
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.635	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	4
UniProt:Q924I2 M4K3			0.611	3
UniProt:Q62910	1	Synj1 [cytosol] (R-RNO-1604634)	0.573	2
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.558	2
UniProt:Q8IUX8 EGFL6			0.553	2
UniProt:Q96J02 ITCH	1	ITCH [cytosol] (R-HSA-975995)	0.526	3
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.508	2
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.508	2
UniProt:Q13443 ADAM9	1	ADAM9 [plasma membrane] (R-HSA-708336)	0.508	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.508	2
UniProt:P22681 CBL	20	CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL del366-409 [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637) CBL G375fs*16 [cytosol] (R-HSA-9706211)	0.499	2

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