Sprouty lures CBL away from EGFR

Stable Identifier
R-HSA-182988
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation.

Literature References
PubMed ID Title Journal Year
12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

Rubin, C, Litvak, V, Medvedovsky, H, Zwang, Y, Lev, S, Yarden, Y

Curr Biol 2003
12234920 Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

Wong, ES, Fong, CW, Lim, J, Yusoff, P, Low, BC, Langdon, WY, Guy, GR

EMBO J 2002
Participants
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Orthologous Events
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