Assembly of EGFR complex in clathrin-coated vesicles

Stable Identifier
R-HSA-182994
Type
Reaction [binding]
Species
Homo sapiens
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CBL-CIN85-Endophilin complex mediates ligand-induced down-regulation of the EGF receptor. The BAR domain of endophilin induces membrane curvature. The three SH3 domains of CIN85 bind to atypical proline-arginine motifs (PxxxPR) present in the carboxyl termini of CBL and CBL-b. In this way, CIN85 clusters CBL molecules, which is crucial for efficient EGFR endocytosis and degradation (Soubeyran et al. 2002).

Literature References
PubMed ID Title Journal Year
11894095 Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

Soubeyran, P, Kowanetz, K, Szymkiewicz, I, Langdon, WY, Dikic, I

Nature 2002
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Orthologous Events
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