Ubiquitination of stimulated EGFR (CBL:GRB2)

Stable Identifier
R-HSA-183036
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain.

Literature References
PubMed ID Title Journal Year
10514377 The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

Joazeiro, CA, Wing, SS, Huang, H, Leverson, JD, Hunter, T, Liu, YC

Science 1999
15021893 Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

Marmor, MD, Yarden, Y

Oncogene 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created