CBL binds to GRB2

Stable Identifier
R-HSA-183052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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CBL binds to GRB2
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CBL binds multiple signalling proteins including GRB2. The CBL:GRB2 complex translocates to the plasma membrane where it can bind to GRB2-specific docking sites on the EGF receptor.

Literature References
PubMed ID Title Journal Year
8621719 p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

Panchamoorthy, G, Fukazawa, T, Miyake, S, Soltoff, S, Reedquist, K, Druker, B, Shoelson, S, Cantley, LC, Band, H

J Biol Chem 1996
Participants
Input
Output
Participant Of
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Orthologous Events
CBL binds to GRB2 (Bos taurus)
CBL binds to GRB2 (Caenorhabditis elegans)
CBL binds to GRB2 (Canis familiaris)
CBL binds to GRB2 (Danio rerio)
CBL binds to GRB2 (Drosophila melanogaster)
CBL binds to GRB2 (Gallus gallus)
CBL binds to GRB2 (Mus musculus)
CBL binds to GRB2 (Rattus norvegicus)
CBL binds to GRB2 (Sus scrofa)
CBL binds to GRB2 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)