CBL binds to GRB2

Stable Identifier
R-HSA-183052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CBL binds multiple signalling proteins including GRB2. The CBL:GRB2 complex translocates to the plasma membrane where it can bind to GRB2-specific docking sites on the EGF receptor.

Literature References
PubMed ID Title Journal Year
8621719 p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

Panchamoorthy, G, Fukazawa, T, Miyake, S, Soltoff, S, Reedquist, K, Druker, B, Shoelson, S, Cantley, LC, Band, H

J Biol Chem 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created