Binding of CBL to EGFR

Stable Identifier
R-HSA-183055
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylation at tyrosine Y1045 of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor.

Literature References
PubMed ID Title Journal Year
15475003 Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

Grovdal, LM, Stang, E, Sorkin, A, Madshus, IH

Exp Cell Res 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created