Reactome | CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

Stable Identifier

R-HSA-183084

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

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Beta-Pix (Cool-1) associates with CBL, which appears to be a critical step in CDC42-mediated inhibition of EGFR ubiquitylation and downregulation. The SH3 domain of Beta-Pix specifically interacts with a proline-arginine motif (PxxxPR) present within CBL, which mediates ubiquitylation and subsequent degradation of Beta-Pix.

Literature References

PubMed ID	Title	Journal	Year
16407834	Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix Schmidt, MH, Husnjak, K, Szymkiewicz, I, Haglund, K, Dikic, I	Oncogene	2006