CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

Stable Identifier
R-HSA-183084
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Beta-Pix (Cool-1) associates with CBL, which appears to be a critical step in CDC42-mediated inhibition of EGFR ubiquitylation and downregulation. The SH3 domain of Beta-Pix specifically interacts with a proline-arginine motif (PxxxPR) present within CBL, which mediates ubiquitylation and subsequent degradation of Beta-Pix.

Literature References
PubMed ID Title Journal Year
16407834 Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix

Schmidt, MH, Husnjak, K, Szymkiewicz, I, Haglund, K, Dikic, I

Oncogene 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created