CDC42:GTP binds CBL:Beta-Pix

Stable Identifier
R-HSA-183094
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
CDC42 lures CBL away from the receptor
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General
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Activated CDC42 binds to Beta-Pix (p85Cool-1), a protein that directly associates with CBL. This inhibits the binding of CBL to the EGF receptor and thus prevents CBL from catalyzing receptor ubiquitination.

Literature References
PubMed ID Title Journal Year
14505571 Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation

Wu, WJ, Tu, S, Cerione, RA

Cell 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created