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STING [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1834940
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
TMEM173, MITA, ERIS
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING:3CLpro dimer [cytosol] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
SARS-CoV-2 3a binds to STING (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
STING binds TRIM32 or TRIM56 (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)
STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
STING binds c-di-GMP (Homo sapiens)
STING:STING [endoplasmic reticulum membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING binds cyclic GMP-AMP (Homo sapiens)
STING:STING [endoplasmic reticulum membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING dimerization (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
STING:STING [endoplasmic reticulum membrane] (Homo sapiens)
STING [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86WV6 STING1
Gene Names
STING1, ERIS, MITA, STING, TMEM173
Chain
chain:1-379
Reference Genes
BioGPS Gene:340061 STING1
CTD Gene:340061 STING1
dbSNP Gene:340061 STING1
ENSEMBL:ENSG00000184584 TMEM173
ENSEMBL_homo_sapiens_GENE:ENSG00000184584.14 STING1
ENSEMBL_homo_sapiens_GENE:ENSG00000288243.1 STING1
HGNC:27962 STING1
KEGG Gene (Homo sapiens):340061 STING1
Monarch:340061 STING1
NCBI Gene:340061 STING1
OMIM:612374 STING1
UCSC:Q86WV6 STING1
Reference Transcript
RefSeq:NM_198282.3 STING1
Other Identifiers
11727044_a_at
17000650
224916_PM_at
224916_at
224929_PM_at
224929_at
2877991
2877992
2877993
2877994
2877995
2877998
2878000
2878002
2878003
2878004
2878005
2878006
2878007
2878008
2878009
340061
65817_at
8114536
A_23_P61371
GE88570
GO:0000045
GO:0000139
GO:0000166
GO:0000421
GO:0002218
GO:0002221
GO:0002230
GO:0002376
GO:0002753
GO:0005215
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005773
GO:0005776
GO:0005777
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006914
GO:0006954
GO:0010468
GO:0015252
GO:0016020
GO:0016239
GO:0019901
GO:0023052
GO:0030659
GO:0030667
GO:0031410
GO:0031625
GO:0032092
GO:0032481
GO:0032728
GO:0033116
GO:0035438
GO:0035458
GO:0035591
GO:0042802
GO:0042803
GO:0043226
GO:0045087
GO:0045944
GO:0048471
GO:0050727
GO:0051091
GO:0051259
GO:0051607
GO:0055085
GO:0060090
GO:0060340
GO:0061507
GO:0061629
GO:0061709
GO:0065003
GO:0071360
GO:0071407
GO:0098542
GO:0140374
GO:0140896
GO:1902554
GO:1902600
GO:1990231
HMNXSV003014562
Hs.86347.1.A1_3p_at
Hs.86347.1.A2_3p_at
ILMN_2145116
PH_hs_0033001
TC05001845.hg
Participates
as an output of
SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)
as an input of
STING binds TRIM32 or TRIM56 (Homo sapiens)
STING dimerization (Homo sapiens)
SARS-CoV-2 3a binds to STING (Homo sapiens)
SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)
as a component of
STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] (Homo sapiens)
STING:STING [endoplasmic reticulum membrane] (Homo sapiens)
STING:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
STING:3CLpro dimer [cytosol] (Homo sapiens)
Other forms of this molecule
TMEM173 [plasma membrane]
TMEM173 [secretory granule membrane]
K63polyUb-STING [endoplasmic reticulum membrane]
K63polyUb-STING [cytoplasmic vesicle membrane]
Inferred To
STING [endoplasmic reticulum membrane]
(Bos taurus)
STING [endoplasmic reticulum membrane]
(Danio rerio)
STING [endoplasmic reticulum membrane]
(Drosophila melanogaster)
STING [endoplasmic reticulum membrane]
(Gallus gallus)
STING [endoplasmic reticulum membrane]
(Mus musculus)
STING [endoplasmic reticulum membrane]
(Rattus norvegicus)
STING [endoplasmic reticulum membrane]
(Xenopus tropicalis)
STING1 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_938023.1
Guide to Pharmacology - Targets
2902
OpenTargets
ENSG00000184584
GeneCards
Q86WV6
HPA
ENSG00000184584-STING1
Ensembl
ENSG00000184584
,
ENSP00000498596
,
ENSP00000499166
,
ENST00000652271
,
ENST00000330794
,
ENST00000672102
,
ENST00000651699
,
ENST00000672865
,
ENSP00000500823
,
ENSP00000331288
,
ENST00000672096
,
ENSP00000500685
,
ENSP00000500793
,
ENSG00000288243
PRO
Q86WV6
Pharos - Targets
Q86WV6
Orphanet
23359
HMDB Protein
HMDBP12695
PDB
6UKM
,
6O8C
,
6UL0
,
4EF4
,
4QXQ
,
7KVX
,
6UKY
,
7A90
,
7SSM
,
8B2J
,
5JEJ
,
4F5W
,
4F9E
,
6CFF
,
4EMT
,
6YDB
,
6MXE
,
6S26
,
6NT5
,
8GJX
,
4QXO
,
4F5Y
,
8A2J
,
6DNK
,
8FLM
,
6UKV
,
7X9Q
,
6DXG
,
7Q85
,
6XNP
,
7KVZ
,
6UKX
,
6Y99
,
8P45
,
4KSY
,
8GT6
,
4LOH
,
4F5D
,
6MX3
,
6YDZ
,
8A2H
,
7T9V
,
8STI
,
4QXP
,
4QXR
,
6UKZ
,
4EF5
,
8IK3
,
6XF3
,
7SHO
,
6Z0Z
,
6O8B
,
7KW1
,
6Z15
,
7R4H
,
6S86
,
6UKU
,
7SII
,
6S27
,
4EMU
,
5BQX
,
7X9P
,
8T5L
,
8A2I
,
4F9G
,
8T5K
,
6YWB
,
6MX0
,
6YEA
,
8A2K
,
6CY7
,
6XF4
,
7SHP
,
4F5E
,
4LOI
,
8STH
,
6DXL
,
7OB3
,
7MHC
,
7Q3B
,
6UKW
,
6YWA
,
7T9U
,
8FLK
,
8GSZ
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86WV6 STING1
5
TMEM173 [plasma membrane]
(R-HSA-6804815)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.961
14
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
0.899
9
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.839
9
UniProt:Q7Z434-1 MAVS
0.78
7
UniProt:P42226 STAT6
6
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
STAT6 [cytosol]
(R-HSA-629625)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
0.631
12
UniProt:O15260 SURF4
5
SURF4 [Golgi membrane]
(R-HSA-6813912)
SURF4 [transport vesicle]
(R-HSA-6813919)
SURF4 [endoplasmic reticulum membrane]
(R-HSA-6813914)
SURF4 [plasma membrane]
(R-HSA-6806264)
SURF4 [azurophil granule membrane]
(R-HSA-6799361)
0.623
3
ChEBI:75947 CG(2'5')
0.558
2
UniProt:P09914 IFIT1
1
IFIT1 [cytosol]
(R-HSA-937341)
0.558
3
ChEBI:75948 CG(2'5')
0.558
2
UniProt:P09913 IFIT2
1
IFIT2 [cytosol]
(R-HSA-1015674)
0.558
3
UniProt:Q9NZ01 TECR
1
TECR [endoplasmic reticulum membrane]
(R-HSA-548663)
0.556
3
UniProt:Q9NV29 TM100
0.556
3
UniProt:B2RUZ4 SMIM1
0.556
3
UniProt:Q96HR9-2 REEP6
0.556
3
UniProt:Q9Y342 PLLP
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q13190 STX5
5
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [cytosol]
(R-HSA-9613991)
0.556
3
UniProt:O95214 LERL1
0.556
3
UniProt:Q9BWQ6 YIPF2
0.556
3
UniProt:P27958-PRO_0000037575
0.543
5
UniProt:Q16666 IFI16
1
IFI16 [cytosol]
(R-HSA-1834934)
0.524
2
UniProt:O95786-1 RIGI
0.524
2
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.499
2
UniProt:P39656 DDOST
3
DDOST [azurophil granule membrane]
(R-HSA-6799145)
DDOST [plasma membrane]
(R-HSA-879386)
DDOST [endoplasmic reticulum membrane]
(R-HSA-264963)
0.499
2
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.499
2
UniProt:Q96N66 MBOAT7
1
MBOAT7 [endoplasmic reticulum membrane]
(R-HSA-1498778)
0.499
2
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.499
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.499
2
UniProt:Q96A33 CCD47
0.499
2
UniProt:P43308 SSR2
1
SSR2 [endoplasmic reticulum membrane]
(R-HSA-265061)
0.482
4
UniProt:P0C6X5-PRO_0000283876 REP
0.463
4
UniProt:Q99IB8-PRO_0000045601
0.463
5
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.463
2
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