Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2.
Deddouche, S, Goubau, D, Reis e Sousa, C
Fitzgerald, KA, Sharma, S
Bowie, AG, Paludan, SR
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