ZMYM2-p-2Y-FGFR1 fusion [cytosol]

Stable Identifier
R-HSA-1839016
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ZMYM2(1-913)-p-FGFR1(429-822) fusion, t(8;13) ZMYM2-p-FGFR1 fusion, ZNF198-p-FGFR1 fusion, ZNF198(1-913)-p-FGFR1(429-822) fusion, t(8;13) ZNF198-p-FGFR1 fusion, FIM-p-FGFR1 fusion, RAMP-p-FGFR1 fusion
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
9716603 Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome

Reiter, A, Sohal, J, Kulkarni, S, Chase, A, Macdonald, DH, Aguiar, RC, Gonçalves, C, Hernandez, JM, Jennings, BA, Goldman, JM, Cross, NC

Blood 1998
9425908 FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

Xiao, S, Nalabolu, SR, Aster, JC, Ma, J, Abruzzo, L, Jaffe, ES, Stone, R, Weissman, SM, Hudson, TJ, Fletcher, JA

Nat Genet 1998
9576949 Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)

Popovici, C, Adelaide, J, Ollendorff, V, Chaffanet, M, Guasch, G, Jacrot, M, Leroux, D, Birnbaum, D, Pébusque, MJ

Proc Natl Acad Sci U S A 1998
External Reference Information
External Reference
UniProt:Q9UBW7 ZMYM2
Gene Names
ZMYM2, FIM, RAMP, ZNF198
Chain
chain:1-1377
Reference Genes
BioGPS Gene:7750 ZMYM2
COSMIC (genes):ZMYM2 ZMYM2
CTD Gene:7750 ZMYM2
dbSNP Gene:7750 ZMYM2
ENSEMBL:ENSG00000121741 ZMYM2
HGNC:12989 ZMYM2
KEGG Gene (Homo sapiens):7750 ZMYM2
Monarch:7750 ZMYM2
NCBI Gene:7750 ZMYM2
OMIM:602221 ZMYM2
UCSC:Q9UBW7 ZMYM2
Reference Transcript
Other Identifiers
0006420609
11739414_a_at
11752025_s_at
11759305_at
11759306_s_at
16772942
202778_s_at
210281_s_at
226512_at
240642_at
242597_at
3480131
3480132
3480133
3480134
3480138
3480141
3480147
3480148
3480149
3480150
3480153
3480154
3480155
3480156
3480157
3480162
3480163
3480165
3480166
3480167
3480168
3480171
3480172
3480173
3480174
3480175
3480176
3480177
3480179
3480182
3480185
3480186
3480187
3480194
3480196
3480197
3480199
3480201
3480202
3480203
3480204
3480243
3480244
3480246
3504069
41436_at
45184_at
48606_at
53216_at
62170_at
7750
7967900
85956_at
A_14_P137536
A_23_P99405
GE495605
GE55255
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0008150
GO:0008270
GO:0016605
GO:0019899
GO:0031624
GO:0043167
GO:0043226
GO:0046872
HMNXSV003026538
HMNXSV003057218
Hs.26490.0.A1_3p_at
Hs.26490.1.A1_3p_at
Hs.41167.0.A1_3p_at
ILMN_1661636
ILMN_2403823
PH_hs_0029730
TC13000021.hg
TC13000927.hg
g4508010_3p_a_at
Participates
as a component of
Other forms of this molecule
ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol]
ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol]
ZMYM2(1-1057)-p-5Y FLT3(586-993) fusion [cytosol]
ZMYM2(1-1059)-p-4Y FLT3(594-993) fusion [cytosol]
ZMYM2-FGFR1 fusion [cytosol]
Modified Residues
Name
Insertion of residues 429 to 822 at 914 from UniProt:P11362 FGFR1
Coordinate
914
Name
O4'-phospho-L-tyrosine at 766
Coordinate
766
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
precursor lymphoblastic lymphoma/leukemia DOID:5600
subacute leukemia DOID:3264
myelodysplastic myeloproliferative cancer DOID:4972 Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
Cross References
RefSeq
OpenTargets
HPA
GeneCards
Ensembl
PRO
Interactors (4)
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