p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

Stable Identifier
R-HSA-1839041
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-Y177-BCR-p-FGFR1 fusion, t(8:22) BCR-p-FGFR1 fusion
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Doody, ML, Demiroglu, A, Carnicero, F, Brody, JP, Melo, JV, Koduru, P, Cross, NC, Heath, C, Hawson, G, Taylor, K, Steer, EJ, Goldman, JM, Reiter, A, Rodwell, R, Bentley, M, Allen, SL

Blood 2001
External Reference Information
External Reference
Gene Names
BCR, BCR1, D22S11
Chain
chain:1-1271
Other Identifiers
11726280_a_at
11726281_x_at
11726282_s_at
11748359_s_at
11749115_x_at
11752764_x_at
11752988_a_at
11752989_x_at
11753006_a_at
11753007_x_at
1333_f_at
16927907
202315_PM_s_at
202315_s_at
2043_s_at
217223_PM_s_at
217223_s_at
226602_PM_s_at
226602_s_at
34679_at
3901466
3937955
3937958
3937959
3937960
3938989
3938997
3939005
3939008
3939177
3939185
3939186
3939187
3939188
3939197
3939199
3939200
3939202
3939203
3939204
3939205
3939212
3939213
3939216
3939217
3939218
3939220
3939222
3939225
3939233
3939235
3939237
3939238
3939241
3939243
3939246
3939247
3939249
3939250
3939251
3939252
3939253
3939979
3939982
3939987
3939989
3939992
3939995
3939996
3952316
3952322
3952331
3952333
3953699
3953702
3954008
3954009
3954014
3955217
3955220
3955224
3955232
537_f_at
613
64904_at
68350_s_at
74612_s_at
754_s_at
8071691
8074730
91639_at
91641_g_at
A_23_P503115
A_24_P127235
A_24_P162073
A_24_P873764
A_32_P56713
GE82611
GE86739
GO:0000166
GO:0002376
GO:0002692
GO:0003013
GO:0003014
GO:0003824
GO:0004674
GO:0004713
GO:0005085
GO:0005096
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005829
GO:0005886
GO:0006468
GO:0006886
GO:0006909
GO:0006954
GO:0007010
GO:0007155
GO:0007165
GO:0007264
GO:0007420
GO:0014069
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0030036
GO:0030154
GO:0030216
GO:0030424
GO:0032496
GO:0032991
GO:0034330
GO:0035023
GO:0035556
GO:0036211
GO:0042472
GO:0042995
GO:0043114
GO:0043197
GO:0043226
GO:0043312
GO:0043314
GO:0043547
GO:0045202
GO:0048041
GO:0048856
GO:0048870
GO:0048872
GO:0050728
GO:0050766
GO:0050804
GO:0050877
GO:0050885
GO:0051056
GO:0051171
GO:0051649
GO:0051726
GO:0055085
GO:0060216
GO:0060268
GO:0060313
GO:0065002
GO:0070062
GO:0071222
GO:0090630
GO:0098685
GO:0098772
GO:0098978
GO:0106310
GO:0140096
GO:1905517
GO:1905522
GO:2000378
HMNXSV003010355
HMNXSV003040590
HMNXSV003058001
Hs.234799.2.S1_3p_a_at
Hs.296429.1.A1_3p_a_at
Hs.296429.1.A1_3p_x_at
ILMN_1668907
ILMN_1670398
ILMN_1680683
ILMN_1792592
ILMN_2333146
PH_hs_0033657
PH_hs_0040337
TC22000129.hg
TC22000154.hg
TC22000587.hg
TC22001011.hg
TC22001012.hg
TC22001014.hg
TC22001027.hg
X02596_at
p33809
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 429 to 822 at 585 from UniProt:P11362 FGFR1
Coordinate
585
Name
O4'-phospho-L-tyrosine at 766
Coordinate
766
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 177
Coordinate
177
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
myelodysplastic myeloproliferative cancer DOID:4972 Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
acute lymphocytic leukemia DOID:9952
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
IntEnz
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (3)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.921 11
 UniProt:P13569 CFTR  17 0.595 5
 UniProt:P04637 TP53  20 0.519 2
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