p-BCR-p-FGFR1 phosphorylates GAB2

Stable Identifier
R-HSA-1839110
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Recruitment of GAB2 to the BCR-FGFR1 fusion protein results in GAB2 phosphorylation (Roumiatnetsev, 2004). As in the case of BCR-ABL (Sattler, 2002), recruitment and phosphorylation of GAB2 is dependent on BCR residue Y177. Deletion of Y177 abolishes GRB2 recruitment and converts the more aggressive MPD disorder induced by BCR-FGFR1 to the EMS characteristic of other FGFR1 fusions (Demiroglu, 2001; Roumianetsev, 2004)

Literature References
PubMed ID Title Journal Year
15050920 Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

Roumiantsev, S, Krause, DS, Neumann, CA, Dimitri, CA, Asiedu, F, Cross, NC, Van Etten, RA

Cancer Cell 2004
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Demiroglu, A, Steer, EJ, Heath, C, Taylor, K, Bentley, M, Allen, SL, Koduru, P, Brody, JP, Hawson, G, Rodwell, R, Doody, ML, Carnicero, F, Reiter, A, Goldman, JM, Melo, JV, Cross, NC

Blood 2001
12124177 Critical role for Gab2 in transformation by BCR/ABL

Sattler, M, Mohi, MG, Pride, YB, Quinnan, LR, Malouf, NA, Podar, K, Gesbert, F, Iwasaki, H, Li, S, Van Etten, RA, Gu, H, Griffin, JD, Neel, BG

Cancer Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
chronic myeloid leukemia 8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created