BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1

Stable Identifier
R-HSA-1839114
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
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Based on analogy with studies of the BCR-ABL fusion, phosphorylated GAB2 recruits the regulatory subunit of PI3K to the BCR-FGFR1 fusion (Sattler, 2002; Demiroglu, 2001; Roumiantsev, 2004).

Literature References
PubMed ID Title Journal Year
15050920 Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

Roumiantsev, S, Krause, DS, Neumann, CA, Dimitri, CA, Asiedu, F, Cross, NC, Van Etten, RA

Cancer Cell 2004
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Demiroglu, A, Steer, EJ, Heath, C, Taylor, K, Bentley, M, Allen, SL, Koduru, P, Brody, JP, Hawson, G, Rodwell, R, Doody, ML, Carnicero, F, Reiter, A, Goldman, JM, Melo, JV, Cross, NC

Blood 2001
12124177 Critical role for Gab2 in transformation by BCR/ABL

Sattler, M, Mohi, MG, Pride, YB, Quinnan, LR, Malouf, NA, Podar, K, Gesbert, F, Iwasaki, H, Li, S, Van Etten, RA, Gu, H, Griffin, JD, Neel, BG

Cancer Cell 2002
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
chronic myeloid leukemia 8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2011-10-27)