5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol

Stable Identifier
R-HSA-1855158
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
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Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 5-triphospho- 1,2,3,4,6-pentakisphosphate (5-PPP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K3 (Saiardi et al. 2001, Draskovic et al. 2008).
Literature References
PubMed ID Title Journal Year
18355727 Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups

Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P

Chem Biol 2008
11502751 Identification and characterization of a novel inositol hexakisphosphate kinase

Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR

J Biol Chem 2001
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Catalyst Activity

inositol 5-diphosphate pentakisphosphate 5-kinase activity of IP6K1/3 [cytosol]

Physical Entity
IP6K1/3 [cytosol] (Homo sapiens)
Activity
inositol 5-diphosphate pentakisphosphate 5-kinase activity (GO:0052836)
Orthologous Events
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Gallus gallus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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