5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol

Stable Identifier
R-HSA-1855182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1/2 (PPIP5K1) and 2 (PPIP5K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Fridy et al. 2007, Mulugu et al. 2007, Choi et al. 2007, Lin et al. 2009).

Literature References
PubMed ID Title Journal Year
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Choi, JH, Williams, J, Cho, J, Falck, JR, Shears, SB

J Biol Chem 2007
18981179 Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases

Lin, H, Fridy, PC, Ribeiro, AA, Choi, JH, Barma, DK, Vogel, G, Falck, JR, Shears, SB, York, JD, Mayr, GW

J Biol Chem 2009
17690096 Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases

Fridy, PC, Otto, JC, Dollins, DE, York, JD

J Biol Chem 2007
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD

Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol heptakisphosphate kinase activity of PPIP5K1/2 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created