I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

Stable Identifier
R-HSA-1855185
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,4,5,6-tetrakisphosphate (I(1,4,5,6)P4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) (Nalaskowski et al. 2002, Chang & Majerus 2006).

Literature References
PubMed ID Title Journal Year
12027805 The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

Nalaskowski, MM, Deschermeier, C, Fanick, W, Mayr, GW

Biochem J 2002
16293229 Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

Chang, SC, Majerus, PW

Biochem Biophys Res Commun 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol tetrakisphosphate 3-kinase activity of IPMK [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created