I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Stable Identifier
R-HSA-1855205
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).

Literature References
PubMed ID Title Journal Year
10866302 Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

Han, SY, Kato, H, Kato, S, Suzuki, T, Shibata, H, Ishii, S, Shiiba, K, Matsuno, S, Kanamaru, R, Ishioka, C

Cancer Res 2000
9593664 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Maehama, T, Dixon, JE

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity of PTEN:Mg2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored